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dc.contributor.authorAfzalian, Neda
dc.contributor.authorRajimehr, Reza
dc.date.accessioned2021-12-09T00:32:37Z
dc.date.available2021-12-09T00:32:37Z
dc.date.issued2021-11-24
dc.identifier.issn0270-6474
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331304
dc.description.abstractExtensive research has shown that perceptual information of faces is processed in a network of hierarchically-organized areas within ventral temporal cortex. For familiar and famous faces, perceptual processing of faces is normally accompanied by extraction of semantic knowledge about the social status of persons. Semantic processing of familiar faces could entail progressive stages of information abstraction. However, the cortical mechanisms supporting multistage processing of familiar faces have not been characterized. Here, using an event-related fMRI experiment, familiar faces from four celebrity groups (actors, singers, politicians, and football players) and unfamiliar faces were presented to the human subjects (both males and females) while they were engaged in a face categorization task. We systematically explored the cortical representations for faces, familiar faces, subcategories of familiar faces, and familiar face identities using whole-brain univariate analysis, searchlight-based multivariate pattern analysis (MVPA), and functional connectivity analysis. Convergent evidence from all these analyses revealed a set of overlapping regions within posterior cingulate cortex (PCC) that contained decodable fMRI responses for representing different levels of semantic knowledge about familiar faces. Our results suggest a multistage pathway in PCC for processing semantic information of faces, analogous to the multistage pathway in ventral temporal cortex for processing perceptual information of faces.SIGNIFICANCE STATEMENT Recognizing familiar faces is an important component of social communications. Previous research has shown that a distributed network of brain areas is involved in processing the semantic information of familiar faces. However, it is not clear how different levels of semantic information are represented in the brain. Here, we evaluated the multivariate response patterns across the entire cortex to discover the areas that contain information for familiar faces, subcategories of familiar faces, and identities of familiar faces. The searchlight maps revealed that different levels of semantic information are represented in topographically adjacent areas within posterior cingulate cortex (PCC). The results suggest that semantic processing of faces is mediated through progressive stages of information abstraction in PCC.
dc.publisherSociety for Neuroscience
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectfMRI
dc.subjectface subcategories
dc.subjectfamiliar faces
dc.subjectmultivariate pattern analysis
dc.subjectposterior cingulate cortex
dc.subjectsemantic processing
dc.titleSpatially Adjacent Regions in Posterior Cingulate Cortex Represent Familiar Faces at Different Levels of Complexity.
dc.typeArticle
dc.publisher.departmentMrc Cognition And Brain Sciences Unit Student
dc.date.updated2021-12-08T13:07:44Z
prism.endingPage9826
prism.issueIdentifier47
prism.publicationDate2021
prism.publicationNameJ Neurosci
prism.startingPage9807
prism.volume41
dc.identifier.doi10.17863/CAM.78751
dcterms.dateAccepted2021-09-26
rioxxterms.versionofrecord10.1523/JNEUROSCI.1580-20.2021
rioxxterms.versionVoR
dc.contributor.orcidRajimehr, Reza [0000-0002-3248-3305]
dc.identifier.eissn1529-2401
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMRC (unknown)
pubs.funder-project-idMedical Research Council (MC_UU_00005/2)
cam.issuedOnline2021-10-20
cam.depositDate2021-12-08
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International