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dc.contributor.authorJones, Jonathan S
dc.contributor.authorThe Calm Team
dc.contributor.authorAstle, Duncan E
dc.date.accessioned2021-12-10T00:30:36Z
dc.date.available2021-12-10T00:30:36Z
dc.date.issued2021-12
dc.identifier.issn1878-9293
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331318
dc.description.abstractBehavioural difficulties are seen as hallmarks of many neurodevelopmental conditions. Differences in functional brain organisation have been observed in these conditions, but little is known about how they are related to a child's profile of behavioural difficulties. We investigated whether behavioural difficulties are associated with how the brain is functionally organised in an intentionally heterogeneous and transdiagnostic sample of 957 children aged 5-15. We used consensus community detection to derive data-driven profiles of behavioural difficulties and constructed functional connectomes from a subset of 238 children with resting-state functional Magnetic Resonance Imaging (fMRI) data. We identified three distinct profiles of behaviour that were characterised by principal difficulties with hot executive function, cool executive function, and learning. Global organisation of the functional connectome did not differ between the groups, but multivariate patterns of connectivity at the level of Intrinsic Connectivity Networks (ICNs), nodes, and hubs significantly predicted group membership in held-out data. Fronto-parietal connector hubs were under-connected in all groups relative to a comparison sample and children with hot vs cool executive function difficulties were distinguished by connectivity in ICNs associated with cognitive control, emotion processing, and social cognition. This demonstrates both general and specific neurodevelopmental risk factors in the functional connectome.
dc.format.mediumPrint-Electronic
dc.publisherElsevier
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBehavioral difficulties
dc.subjectExecutive function
dc.subjectFunctional connectivity
dc.subjectNeurodevelopment
dc.titleA transdiagnostic data-driven study of children's behaviour and the functional connectome.
dc.typeArticle
dc.publisher.departmentMrc Cognition And Brain Sciences Unit
dc.date.updated2021-12-08T11:07:44Z
prism.numberARTN 101027
prism.publicationDate2021
prism.publicationNameDevelopmental Cognitive Neuroscience
prism.startingPage101027
prism.volume52
dc.identifier.doi10.17863/CAM.78766
dcterms.dateAccepted2021-10-19
rioxxterms.versionofrecord10.1016/j.dcn.2021.101027
rioxxterms.versionVoR
dc.contributor.orcidAstle, Duncan [0000-0002-7042-5392]
dc.identifier.eissn1878-9307
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMRC (unknown)
pubs.funder-project-idMedical Research Council (MC_UU_00005/2)
cam.issuedOnline2021-10-22
cam.depositDate2021-12-08
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International