Distinguishing causation from genetic correlation in a Mendelian randomisation framework.
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Publication Date
2021-12Journal Title
Eur Respir J
ISSN
0903-1936
Publisher
European Respiratory Society (ERS)
Volume
58
Issue
6
Pages
2101346-2101346
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Gill, D., & Burgess, S. (2021). Distinguishing causation from genetic correlation in a Mendelian randomisation framework.. Eur Respir J, 58 (6), 2101346-2101346. https://doi.org/10.1183/13993003.01346-2021
Abstract
The kidney is involved in a number of physiological processes, including fluid and electrolyte balance. Kidney function has been associated with obstructive airways disease, however the nature of this relationship has been difficult to unpick. Specifically, it is unclear whether kidney function affects airways disease, vice versa, or whether the association is instead attributable to confounding factors. Insight into the nature of this relationship is of clinical relevance, as the identification of renal impairment as a causal risk factor for obstructive lung disease would offer mechanistic insight and therapeutic opportunities. However, conventional observational studies exploring this have been unable to infer causation, due to the possibility of unmeasured or unknown environmental confounding and reverse causation.
Keywords
Humans, Mendelian Randomization Analysis, Risk Factors
Sponsorship
Wellcome Trust (204623/Z/16/Z)
Medical Research Council (MC_UU_00002/7)
British Heart Foundation (None)
British Heart Foundation (CH/12/2/29428)
British Heart Foundation (RG/18/13/33946)
Identifiers
External DOI: https://doi.org/10.1183/13993003.01346-2021
This record's URL: https://www.repository.cam.ac.uk/handle/1810/331335
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