Show simple item record

dc.contributor.authorWalklate, Jonathan
dc.contributor.authorFerrantini, Cecilia
dc.contributor.authorJohnson, Chloe A
dc.contributor.authorTesi, Chiara
dc.contributor.authorPoggesi, Corrado
dc.contributor.authorGeeves, Michael A
dc.date.accessioned2021-12-15T11:10:40Z
dc.date.available2021-12-15T11:10:40Z
dc.date.issued2021-12
dc.date.submitted2021-04-21
dc.identifier.issn1420-682X
dc.identifier.others00018-021-03971-y
dc.identifier.other3971
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331465
dc.description.abstractHuman atrial and ventricular contractions have distinct mechanical characteristics including speed of contraction, volume of blood delivered and the range of pressure generated. Notably, the ventricle expresses predominantly β-cardiac myosin while the atrium expresses mostly the α-isoform. In recent years exploration of the properties of pure α- & β-myosin isoforms have been possible in solution, in isolated myocytes and myofibrils. This allows us to consider the extent to which the atrial vs ventricular mechanical characteristics are defined by the myosin isoform expressed, and how the isoform properties are matched to their physiological roles. To do this we Outline the essential feature of atrial and ventricular contraction; Explore the molecular structural and functional characteristics of the two myosin isoforms; Describe the contractile behaviour of myocytes and myofibrils expressing a single myosin isoform; Finally we outline the outstanding problems in defining the differences between the atria and ventricles. This allowed us consider what features of contraction can and cannot be ascribed to the myosin isoforms present in the atria and ventricles.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectReview
dc.subjectHeart
dc.subjectMyosin-structure–function
dc.subjectCardiomyocytes
dc.subjectCardiac proteins
dc.titleAlpha and beta myosin isoforms and human atrial and ventricular contraction.
dc.typeArticle
dc.date.updated2021-12-15T11:10:40Z
prism.endingPage7337
prism.issueIdentifier23
prism.publicationNameCell Mol Life Sci
prism.startingPage7309
prism.volume78
dc.identifier.doi10.17863/CAM.78919
dcterms.dateAccepted2021-10-08
rioxxterms.versionofrecord10.1007/s00018-021-03971-y
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidWalklate, Jonathan [0000-0002-2532-8446]
dc.contributor.orcidFerrantini, Cecilia [0000-0002-3757-1363]
dc.contributor.orcidJohnson, Chloe A [0000-0003-0856-5041]
dc.contributor.orcidTesi, Chiara [0000-0002-1111-1473]
dc.contributor.orcidPoggesi, Corrado [0000-0003-2624-4778]
dc.contributor.orcidGeeves, Michael A [0000-0002-9364-8898]
dc.identifier.eissn1420-9071
pubs.funder-project-idHorizon 2020 (777204 SILICO FCM)
cam.issuedOnline2021-10-26


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record