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dc.contributor.authorDomínguez-Gil, Beatriz
dc.contributor.authorAscher, Nancy
dc.contributor.authorCapron, Alexander M
dc.contributor.authorGardiner, Dale
dc.contributor.authorManara, Alexander R
dc.contributor.authorBernat, James L
dc.contributor.authorMiñambres, Eduardo
dc.contributor.authorSingh, Jeffrey M
dc.contributor.authorPorte, Robert J
dc.contributor.authorMarkmann, James F
dc.contributor.authorDhital, Kumud
dc.contributor.authorLedoux, Didier
dc.contributor.authorFondevila, Constantino
dc.contributor.authorHosgood, Sarah
dc.contributor.authorVan Raemdonck, Dirk
dc.contributor.authorKeshavjee, Shaf
dc.contributor.authorDubois, James
dc.contributor.authorMcGee, Andrew
dc.contributor.authorHenderson, Galen V
dc.contributor.authorGlazier, Alexandra K
dc.contributor.authorTullius, Stefan G
dc.contributor.authorShemie, Sam D
dc.contributor.authorDelmonico, Francis L
dc.date.accessioned2021-12-15T16:27:20Z
dc.date.available2021-12-15T16:27:20Z
dc.date.issued2021-03
dc.date.submitted2020-09-27
dc.identifier.issn0342-4642
dc.identifier.others00134-020-06341-7
dc.identifier.other6341
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331523
dc.description.abstractA decision to withdraw life-sustaining treatment (WLST) is derived by a conclusion that further treatment will not enable a patient to survive or will not produce a functional outcome with acceptable quality of life that the patient and the treating team regard as beneficial. Although many hospitalized patients die under such circumstances, controlled donation after the circulatory determination of death (cDCDD) programs have been developed only in a reduced number of countries. This International Collaborative Statement aims at expanding cDCDD in the world to help countries progress towards self-sufficiency in transplantation and offer more patients the opportunity of organ donation. The Statement addresses three fundamental aspects of the cDCDD pathway. First, it describes the process of determining a prognosis that justifies the WLST, a decision that should be prior to and independent of any consideration of organ donation and in which transplant professionals must not participate. Second, the Statement establishes the permanent cessation of circulation to the brain as the standard to determine death by circulatory criteria. Death may be declared after an elapsed observation period of 5 min without circulation to the brain, which confirms that the absence of circulation to the brain is permanent. Finally, the Statement highlights the value of perfusion repair for increasing the success of cDCDD organ transplantation. cDCDD protocols may utilize either in situ or ex situ perfusion consistent with the practice of each country. Methods to accomplish the in situ normothermic reperfusion of organs must preclude the restoration of brain perfusion to not invalidate the determination of death.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectConference Reports and Expert Panel
dc.subjectDetermination of death
dc.subjectDonation after the circulatory determination of death
dc.subjectNormothermic regional perfusion
dc.subjectOrgan perfusion
dc.subjectOrgan repair
dc.subjectOrgan transplantation
dc.subjectTissue and organ procurement
dc.subjectWithdrawal of life-sustaining therapy
dc.titleExpanding controlled donation after the circulatory determination of death: statement from an international collaborative.
dc.typeOther
dc.date.updated2021-12-15T16:27:20Z
prism.endingPage281
prism.issueIdentifier3
prism.publicationNameIntensive Care Med
prism.startingPage265
prism.volume47
dc.identifier.doi10.17863/CAM.78977
dcterms.dateAccepted2020-12-21
rioxxterms.versionofrecord10.1007/s00134-020-06341-7
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.contributor.orcidDomínguez-Gil, Beatriz [0000-0002-5695-8993]
dc.identifier.eissn1432-1238
cam.issuedOnline2021-02-26


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