Seroprevalence of anti-SARS-CoV-2 IgG at the first epidemic peak in French Guiana, July 2020.
Alves Sarmento, Christelle
PLoS Negl Trop Dis
Public Library of Science (PLoS)
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Flamand, C., Alves Sarmento, C., Enfissi, A., Bailly, S., Beillard, E., Gaillet, M., Michaud, C., et al. (2021). Seroprevalence of anti-SARS-CoV-2 IgG at the first epidemic peak in French Guiana, July 2020.. PLoS Negl Trop Dis, 15 (11) https://doi.org/10.1371/journal.pntd.0009945
Funder: National Research Agency
Funder: Regional Health Agency of French Guiana
Funder: Institut Pasteur Urgence COVID-19 fundraising
BACKGROUND: While Latin America has been heavily affected by the pandemic, only a few seroprevalence studies have been conducted there during the first epidemic wave in the first half of 2020. METHODOLOGY/PRINCIPAL FINDINGS: A cross-sectional survey was performed between 15 July 2020 and 23 July 2020 among individuals who visited 4 medical laboratories or 5 health centers for routine screening or clinical management, with the exception of symptomatic suggestive cases of covid-19. Samples were screened for the presence of anti-SARS-CoV-2 IgG directed against domain S1 of the SARS-CoV-2 spike protein using the anti-SARS-CoV-2 enzyme-linked immunosorbent assay (ELISA) from Euroimmun. CONCLUSIONS/SIGNIFICANCE: The overall seroprevalence was 15.4% [9.3%-24.4%] among 480 participants, ranging from 4.0% to 25.5% across the different municipalities. The seroprevalence did not differ according to gender (p = 0.19) or age (p = 0.51). Among SARS-CoV-2 positive individuals, we found that 24.6% [11.5%-45.2%] reported symptoms consistent with COVID-19. Our findings revealed high levels of infection across the territory but a low number of resulting deaths, which can be explained by French Guiana's young population structure.
Research Article, Biology and life sciences, Medicine and health sciences, Research and analysis methods
European Regional Development Fund (GY0027257)
External DOI: https://doi.org/10.1371/journal.pntd.0009945
This record's URL: https://www.repository.cam.ac.uk/handle/1810/331686