Activity-induced instabilities of brain organoids.

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Authors
  Thijssen, Kristian
  Kusters, Guido LA
  Doostmohammadi, Amin
Publication Date
2021-12-07
Journal Title
Eur Phys J E Soft Matter
ISSN
1292-8941
Publisher
Springer Science and Business Media LLC
Volume
44
Issue
12
Language
en
Type
Article
This Version
VoR
Metadata
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Citation
Thijssen, K., Kusters, G. L., & Doostmohammadi, A. (2021). Activity-induced instabilities of brain organoids.. Eur Phys J E Soft Matter, 44 (12) https://doi.org/10.1140/epje/s10189-021-00149-z
Description
Funder: http://dx.doi.org/10.13039/501100007601; doi: Horizon 2020; Grant(s): 722497
Funder: Dutch Research Council (NWO) in the framework of the ENW PPP Fund for the top sectors and from the Ministry of Economic Affairs in the framework of the ‘PPS-Toeslagregeling’.
Abstract
We present an analytical and numerical investigation of the activity-induced hydrodynamic instabilities in model brain organoids. While several mechanisms have been introduced to explain the experimental observation of surface instabilities in brain organoids, the role of activity has been largely overlooked. Our results show that the active stress generated by the cells can be a, previously overlooked, contributor to the emergence of surface deformations in brain organoids.
Keywords
Regular Article - Living Systems, Tissue Mechanics
Sponsorship
EPSRC (EP/T031247/1)
Identifiers
s10189-021-00149-z, 149
External DOI: https://doi.org/10.1140/epje/s10189-021-00149-z
This record's URL: https://www.repository.cam.ac.uk/handle/1810/331798
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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