Activity-induced instabilities of brain organoids.
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Type
Article
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Abstract
We present an analytical and numerical investigation of the activity-induced hydrodynamic instabilities in model brain organoids. While several mechanisms have been introduced to explain the experimental observation of surface instabilities in brain organoids, the role of activity has been largely overlooked. Our results show that the active stress generated by the cells can be a, previously overlooked, contributor to the emergence of surface deformations in brain organoids.
Publication Date
2021-12-07
Online Publication Date
2021-12-07
Acceptance Date
2021-11-15
Keywords
Regular Article - Living Systems, Tissue Mechanics
Journal Title
Eur Phys J E Soft Matter
Journal ISSN
1292-8941
1292-895X
1292-895X
Volume Title
44
Publisher
Springer Science and Business Media LLC
Sponsorship
EPSRC (EP/T031247/1)