Activity-induced instabilities of brain organoids.

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dc.contributor.authorThijssen, Kristian
dc.contributor.authorKusters, Guido LA
dc.contributor.authorDoostmohammadi, Amin
dc.date.accessioned2021-12-24T14:36:49Z
dc.date.available2021-12-24T14:36:49Z
dc.date.issued2021-12-07
dc.date.submitted2021-08-06
dc.identifier.issn1292-8941
dc.identifier.others10189-021-00149-z
dc.identifier.other149
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331798
dc.descriptionFunder: http://dx.doi.org/10.13039/501100007601; doi: Horizon 2020; Grant(s): 722497
dc.descriptionFunder: Dutch Research Council (NWO) in the framework of the ENW PPP Fund for the top sectors and from the Ministry of Economic Affairs in the framework of the ‘PPS-Toeslagregeling’.
dc.description.abstractWe present an analytical and numerical investigation of the activity-induced hydrodynamic instabilities in model brain organoids. While several mechanisms have been introduced to explain the experimental observation of surface instabilities in brain organoids, the role of activity has been largely overlooked. Our results show that the active stress generated by the cells can be a, previously overlooked, contributor to the emergence of surface deformations in brain organoids.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectRegular Article - Living Systems
dc.subjectTissue Mechanics
dc.titleActivity-induced instabilities of brain organoids.
dc.typeArticle
dc.date.updated2021-12-24T14:36:48Z
prism.issueIdentifier12
prism.publicationNameEur Phys J E Soft Matter
prism.volume44
dc.identifier.doi10.17863/CAM.79247
dcterms.dateAccepted2021-11-15
rioxxterms.versionofrecord10.1140/epje/s10189-021-00149-z
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidThijssen, Kristian [0000-0001-9636-8624]
dc.contributor.orcidKusters, Guido LA [0000-0002-6004-9768]
dc.contributor.orcidDoostmohammadi, Amin [0000-0002-1116-4268]
dc.identifier.eissn1292-895X
pubs.funder-project-idEPSRC (EP/T031247/1)
cam.issuedOnline2021-12-07


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