Activity-induced instabilities of brain organoids.
dc.contributor.author | Thijssen, Kristian | |
dc.contributor.author | Kusters, Guido LA | |
dc.contributor.author | Doostmohammadi, Amin | |
dc.date.accessioned | 2021-12-24T14:36:49Z | |
dc.date.available | 2021-12-24T14:36:49Z | |
dc.date.issued | 2021-12-07 | |
dc.date.submitted | 2021-08-06 | |
dc.identifier.issn | 1292-8941 | |
dc.identifier.other | s10189-021-00149-z | |
dc.identifier.other | 149 | |
dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/331798 | |
dc.description | Funder: http://dx.doi.org/10.13039/501100007601; doi: Horizon 2020; Grant(s): 722497 | |
dc.description | Funder: Dutch Research Council (NWO) in the framework of the ENW PPP Fund for the top sectors and from the Ministry of Economic Affairs in the framework of the ‘PPS-Toeslagregeling’. | |
dc.description.abstract | We present an analytical and numerical investigation of the activity-induced hydrodynamic instabilities in model brain organoids. While several mechanisms have been introduced to explain the experimental observation of surface instabilities in brain organoids, the role of activity has been largely overlooked. Our results show that the active stress generated by the cells can be a, previously overlooked, contributor to the emergence of surface deformations in brain organoids. | |
dc.language | en | |
dc.publisher | Springer Science and Business Media LLC | |
dc.subject | Regular Article - Living Systems | |
dc.subject | Tissue Mechanics | |
dc.title | Activity-induced instabilities of brain organoids. | |
dc.type | Article | |
dc.date.updated | 2021-12-24T14:36:48Z | |
prism.issueIdentifier | 12 | |
prism.publicationName | Eur Phys J E Soft Matter | |
prism.volume | 44 | |
dc.identifier.doi | 10.17863/CAM.79247 | |
dcterms.dateAccepted | 2021-11-15 | |
rioxxterms.versionofrecord | 10.1140/epje/s10189-021-00149-z | |
rioxxterms.version | VoR | |
rioxxterms.licenseref.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.contributor.orcid | Thijssen, Kristian [0000-0001-9636-8624] | |
dc.contributor.orcid | Kusters, Guido LA [0000-0002-6004-9768] | |
dc.contributor.orcid | Doostmohammadi, Amin [0000-0002-1116-4268] | |
dc.identifier.eissn | 1292-895X | |
pubs.funder-project-id | EPSRC (EP/T031247/1) | |
cam.issuedOnline | 2021-12-07 |
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