Activity-induced instabilities of brain organoids.
Thijssen, Kristian https://orcid.org/0000-0001-9636-8624
Kusters, Guido LA https://orcid.org/0000-0002-6004-9768
Doostmohammadi, Amin https://orcid.org/0000-0002-1116-4268
We present an analytical and numerical investigation of the activity-induced hydrodynamic instabilities in model brain organoids. While several mechanisms have been introduced to explain the experimental observation of surface instabilities in brain organoids, the role of activity has been largely overlooked. Our results show that the active stress generated by the cells can be a, previously overlooked, contributor to the emergence of surface deformations in brain organoids.
Online Publication Date
Regular Article - Living Systems, Tissue Mechanics
Eur Phys J E Soft Matter
Springer Science and Business Media LLC