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dc.contributor.authorBenussi, Alberto
dc.contributor.authorAlberici, Antonella
dc.contributor.authorSamra, Kiran
dc.contributor.authorRussell, Lucy L
dc.contributor.authorGreaves, Caroline V
dc.contributor.authorBocchetta, Martina
dc.contributor.authorDucharme, Simon
dc.contributor.authorFinger, Elizabeth
dc.contributor.authorFumagalli, Giorgio
dc.contributor.authorGalimberti, Daniela
dc.contributor.authorJiskoot, Lize C
dc.contributor.authorLe Ber, Isabelle
dc.contributor.authorMasellis, Mario
dc.contributor.authorNacmias, Benedetta
dc.contributor.authorRowe, James
dc.contributor.authorSanchez-Valle, Raquel
dc.contributor.authorSeelaar, Harro
dc.contributor.authorSynofzik, Matthis
dc.contributor.authorGENFI Consortium
dc.contributor.authorRohrer, Jonathan D
dc.contributor.authorBorroni, Barbara
dc.date.accessioned2021-12-24T14:37:45Z
dc.date.available2021-12-24T14:37:45Z
dc.date.issued2021-12-07
dc.date.submitted2021-03-23
dc.identifier.issn1552-5260
dc.identifier.otheralz12485
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331806
dc.descriptionFunder: EU Joint Programme – Neurodegenerative Disease Research; Id: http://dx.doi.org/10.13039/100013278
dc.descriptionFunder: UK Dementia Research Institute; Id: http://dx.doi.org/10.13039/501100017510
dc.description.abstractThe presymptomatic stages of frontotemporal dementia (FTD) are still poorly defined and encompass a long accrual of progressive biological (preclinical) and then clinical (prodromal) changes, antedating the onset of dementia. The heterogeneity of clinical presentations and the different neuropathological phenotypes have prevented a prior clear description of either preclinical or prodromal FTD. Recent advances in therapeutic approaches, at least in monogenic disease, demand a proper definition of these predementia stages. It has become clear that a consensus lexicon is needed to comprehensively describe the stages that anticipate dementia. The goal of the present work is to review existing literature on the preclinical and prodromal phases of FTD, providing recommendations to address the unmet questions, therefore laying out a strategy for operationalizing and better characterizing these presymptomatic disease stages.
dc.languageen
dc.publisherWiley
dc.subjectPERSPECTIVE
dc.subjectPERSPECTIVES
dc.subjectdefinition
dc.subjectfrontotemporal dementia
dc.subjectfrontotemporal lobar degeneration
dc.subjectmild cognitive and/or behavioral and/or motor impairment
dc.subjectmild cognitive impairment
dc.subjectpreclinical
dc.subjectpresymptomatic
dc.subjectprodromal
dc.titleConceptual framework for the definition of preclinical and prodromal frontotemporal dementia.
dc.typeArticle
dc.date.updated2021-12-24T14:37:44Z
prism.publicationNameAlzheimers Dement
dc.identifier.doi10.17863/CAM.79255
dcterms.dateAccepted2021-08-30
rioxxterms.versionofrecord10.1002/alz.12485
rioxxterms.versionAO
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidRowe, James [0000-0001-7216-8679]
dc.identifier.eissn1552-5279
pubs.funder-project-idMRC (unknown)
pubs.funder-project-idMedical Research Council (MR/J009482/1)
cam.issuedOnline2021-12-07


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