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Conceptual framework for the definition of preclinical and prodromal frontotemporal dementia.

Published version
Peer-reviewed

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Authors

Benussi, Alberto 
Alberici, Antonella 
Samra, Kiran 
Russell, Lucy L 
Greaves, Caroline V 

Abstract

The presymptomatic stages of frontotemporal dementia (FTD) are still poorly defined and encompass a long accrual of progressive biological (preclinical) and then clinical (prodromal) changes, antedating the onset of dementia. The heterogeneity of clinical presentations and the different neuropathological phenotypes have prevented a prior clear description of either preclinical or prodromal FTD. Recent advances in therapeutic approaches, at least in monogenic disease, demand a proper definition of these predementia stages. It has become clear that a consensus lexicon is needed to comprehensively describe the stages that anticipate dementia. The goal of the present work is to review existing literature on the preclinical and prodromal phases of FTD, providing recommendations to address the unmet questions, therefore laying out a strategy for operationalizing and better characterizing these presymptomatic disease stages.

Description

Funder: EU Joint Programme – Neurodegenerative Disease Research; Id: http://dx.doi.org/10.13039/100013278


Funder: UK Dementia Research Institute; Id: http://dx.doi.org/10.13039/501100017510

Keywords

definition, frontotemporal dementia, frontotemporal lobar degeneration, mild cognitive and/or behavioral and/or motor impairment, mild cognitive impairment, preclinical, presymptomatic, prodromal, Frontotemporal Dementia, Humans, Prodromal Symptoms

Journal Title

Alzheimers Dement

Conference Name

Journal ISSN

1552-5260
1552-5279

Volume Title

Publisher

Wiley
Sponsorship
MRC (unknown)
Medical Research Council (MR/J009482/1)