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dc.contributor.authorPalacios-Filardo, Jon
dc.contributor.authorUdakis, Matt
dc.contributor.authorBrown, Giles A
dc.contributor.authorTehan, Benjamin G
dc.contributor.authorCongreve, Miles S
dc.contributor.authorNathan, Pradeep J
dc.contributor.authorBrown, Alastair JH
dc.contributor.authorMellor, Jack R
dc.date.accessioned2021-12-24T14:39:23Z
dc.date.available2021-12-24T14:39:23Z
dc.date.issued2021-09-16
dc.date.submitted2020-01-16
dc.identifier.issn2041-1723
dc.identifier.others41467-021-25280-5
dc.identifier.other25280
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331826
dc.description.abstractAcetylcholine release in the hippocampus plays a central role in the formation of new memory representations. An influential but largely untested theory proposes that memory formation requires acetylcholine to enhance responses in CA1 to new sensory information from entorhinal cortex whilst depressing inputs from previously encoded representations in CA3. Here, we show that excitatory inputs from entorhinal cortex and CA3 are depressed equally by synaptic release of acetylcholine in CA1. However, feedforward inhibition from entorhinal cortex exhibits greater depression than CA3 resulting in a selective enhancement of excitatory-inhibitory balance and CA1 activation by entorhinal inputs. Entorhinal and CA3 pathways engage different feedforward interneuron subpopulations and cholinergic modulation of presynaptic function is mediated differentially by muscarinic M3 and M4 receptors, respectively. Thus, our data support a role and mechanisms for acetylcholine to prioritise novel information inputs to CA1 during memory formation.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectArticle
dc.subject/631/378
dc.subject/631/378/87
dc.subject/631/378/3920
dc.subject/631/378/548
dc.subject/9/74
dc.subjectarticle
dc.titleAcetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits.
dc.typeArticle
dc.date.updated2021-12-24T14:39:22Z
prism.issueIdentifier1
prism.publicationNameNat Commun
prism.volume12
dc.identifier.doi10.17863/CAM.79275
dcterms.dateAccepted2021-07-21
rioxxterms.versionofrecord10.1038/s41467-021-25280-5
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidMellor, Jack R [0000-0002-7706-8105]
dc.identifier.eissn2041-1723
pubs.funder-project-idWellcome Trust (Wellcome) (101029)
cam.issuedOnline2021-09-16


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