Primary orthostatic tremor and orthostatic tremor-plus in dogs: 60 cases (2003-2020).
Authors
Cozzi, Francesca
Publication Date
2022-01Journal Title
J Vet Intern Med
ISSN
0891-6640
Publisher
Wiley
Language
en
Type
Article
This Version
AO
VoR
Metadata
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Liatis, T., Gutierrez-Quintana, R., Mari, L., Czopowicz, M., Polidoro, D., Bhatti, S. F., Cozzi, F., et al. (2022). Primary orthostatic tremor and orthostatic tremor-plus in dogs: 60 cases (2003-2020).. J Vet Intern Med https://doi.org/10.1111/jvim.16328
Abstract
BACKGROUND: Orthostatic tremor (OT) is a rare movement disorder characterized by high-frequency (>12 Hz) involuntary, rhythmic, sinusoidal movements affecting predominantly the limbs while standing. OBJECTIVE: To describe the signalment, presenting complaints, phenotype, diagnostic findings, treatment, and outcome of a large sample of dogs with OT. ANIMALS: Sixty dogs diagnosed with OT based on conscious electromyography. METHODS: Multicenter retrospective case series study. Dogs were included if they had a conscious electromyography consistent with muscle discharge frequency >12 Hz while standing. RESULTS: Fifty-three cases were diagnosed with primary OT (POT). Giant breed dogs represented most cases (83%; 44/53). Most dogs (79%; 42/53) were younger than 2 years of age at onset of signs, except for Retrievers which were all older than 3.5 years of age. The most common presenting complaints were pelvic limb tremors while standing (85%; 45/53) and difficulty when rising or sitting down (45%; 24/53). Improvement of clinical signs occurred in most dogs (85%; 45/53) treated medically with phenobarbital, primidone, gabapentin, pregabalin or clonazepam, but it was mostly partial rather than complete. Orthostatic tremor-plus was seen in 7 dogs that had concurrent neurological diseases. CONCLUSIONS AND CLINICAL IMPORTANCE: Primary OT is a progressive disease of young, purebred, giant/large-breed dogs, which appears to begin later in life in Retrievers. Primary OT apparently responds partially to medications. Orthostatic tremor-plus exists in dogs and can be concomitant or associated with other neurological diseases.
Keywords
STANDARD ARTICLE, STANDARD ARTICLES, canine, paroxysmal movement disorders, postural tremor, shaky legs syndrome, tremor syndromes
Identifiers
jvim16328
External DOI: https://doi.org/10.1111/jvim.16328
This record's URL: https://www.repository.cam.ac.uk/handle/1810/331888
Rights
Licence:
http://creativecommons.org/licenses/by-nc-nd/4.0/
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