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dc.contributor.authorUdovicic, Ivo
dc.contributor.authorStanojevic, Ivan
dc.contributor.authorDjordjevic, Dragan
dc.contributor.authorZeba, Snjezana
dc.contributor.authorRondovic, Goran
dc.contributor.authorAbazovic, Tanja
dc.contributor.authorLazic, Srdjan
dc.contributor.authorVojvodic, Danilo
dc.contributor.authorTo, Kendrick
dc.contributor.authorAbazovic, Dzihan
dc.contributor.authorKhan, Wasim
dc.contributor.authorSurbatovic, Maja
dc.date.accessioned2022-01-04T14:32:17Z
dc.date.available2022-01-04T14:32:17Z
dc.date.issued2021-12-12
dc.identifier.issn2077-0383
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331895
dc.description.abstractImmune cells and mediators play a crucial role in the critical care setting but are understudied. This review explores the concept of sepsis and/or injury-induced immunosuppression and immuno-inflammatory response in COVID-19 and reiterates the need for more accurate functional immunomonitoring of monocyte and neutrophil function in these critically ill patients. in addition, the feasibility of circulating and cell-surface immune biomarkers as predictors of infection and/or outcome in critically ill patients is explored. It is clear that, for critically ill, one size does not fit all and that immune phenotyping of critically ill patients may allow the development of a more personalized approach with tailored immunotherapy for the specific patient. In addition, at this point in time, caution is advised regarding the quality of evidence of some COVID-19 studies in the literature.
dc.languageen
dc.publisherMDPI AG
dc.subjectsepsis
dc.subjecttrauma
dc.subjectCOVID-19
dc.subjectmonitoring
dc.subjectimmunologic
dc.subjectbiomarkers
dc.subjectimmunosuppression
dc.subjectimmunotherapy
dc.subjecttherapy
dc.subjectcritical illness
dc.titleImmunomonitoring of Monocyte and Neutrophil Function in Critically Ill Patients: From Sepsis and/or Trauma to COVID-19.
dc.typeArticle
dc.date.updated2022-01-04T14:32:17Z
prism.issueIdentifier24
prism.publicationNameJ Clin Med
prism.volume10
dc.identifier.doi10.17863/CAM.79345
dcterms.dateAccepted2021-12-01
rioxxterms.versionofrecord10.3390/jcm10245815
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn2077-0383
cam.issuedOnline2021-12-12


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