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dc.contributor.authorLeigh, Kendra
dc.contributor.authorModis, Yorgo
dc.date.accessioned2022-01-04T14:32:45Z
dc.date.available2022-01-04T14:32:45Z
dc.date.issued2021-12-06
dc.identifier.issn2042-8898
dc.identifier.otherrsfs20210019
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331899
dc.description.abstractThe SARS-CoV-2 pandemic has had a global impact and has put scientific endeavour in the spotlight, perhaps more than any previous viral outbreak. Fortuitously, the pandemic came at a time when decades of research in multiple scientific fields could be rapidly brought to bear, and a new generation of vaccine platforms was on the cusp of clinical maturity. SARS-CoV-2 also emerged at the inflection point of a technological revolution in macromolecular imaging by cryo-electron microscopy, fuelled by a confluence of major technological advances in sample preparation, optics, detectors and image processing software, that complemented pre-existing techniques. Together, these advances enabled us to visualize SARS-CoV-2 and its components more rapidly, in greater detail, and in a wider variety of biologically relevant contexts than would have been possible even a few years earlier. The resulting ultrastructural information on SARS-CoV-2 and how it interacts with the host cell has played a critical role in the much-needed accelerated development of COVID-19 vaccines and therapeutics. Here, we review key imaging modalities used to visualize SARS-CoV-2 and present select example data, which have provided us with an exceptionally detailed picture of this virus.
dc.languageen
dc.publisherThe Royal Society
dc.subjectARTICLES
dc.subjectReview articles
dc.subjectSARS-CoV-2
dc.subjectstructural biology
dc.subjectcryo-electron tomography
dc.subjectX-ray crystallography
dc.subjectcryo-electron microscopy
dc.subjectmultiscale imaging
dc.titleImaging and visualizing SARS-CoV-2 in a new era for structural biology.
dc.typeArticle
dc.date.updated2022-01-04T14:32:44Z
prism.issueIdentifier6
prism.publicationNameInterface Focus
prism.volume11
dc.identifier.doi10.17863/CAM.79349
dcterms.dateAccepted2021-08-19
rioxxterms.versionofrecord10.1098/rsfs.2021.0019
rioxxterms.versionAO
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidLeigh, Kendra [0000-0002-6467-3330]
dc.contributor.orcidModis, Yorgo [0000-0002-6084-0429]
dc.identifier.eissn2042-8901
pubs.funder-project-idWellcome Trust (217191/Z/19/Z)
cam.issuedOnline2021-10-12


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