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dc.contributor.authorBenussi, Alberto
dc.contributor.authorAlberici, Antonella
dc.contributor.authorSamra, Kiran
dc.contributor.authorRussell, Lucy L
dc.contributor.authorGreaves, Caroline V
dc.contributor.authorBocchetta, Martina
dc.contributor.authorDucharme, Simon
dc.contributor.authorFinger, Elizabeth
dc.contributor.authorFumagalli, Giorgio
dc.contributor.authorGalimberti, Daniela
dc.contributor.authorJiskoot, Lize C
dc.contributor.authorLe Ber, Isabelle
dc.contributor.authorMasellis, Mario
dc.contributor.authorNacmias, Benedetta
dc.contributor.authorRowe, James
dc.contributor.authorSanchez-Valle, Raquel
dc.contributor.authorSeelaar, Harro
dc.contributor.authorSynofzik, Matthis
dc.contributor.authorGENFI Consortium
dc.contributor.authorRohrer, Jonathan D
dc.contributor.authorBorroni, Barbara
dc.date.accessioned2022-01-05T00:30:46Z
dc.date.available2022-01-05T00:30:46Z
dc.date.issued2021-12-07
dc.identifier.issn1552-5260
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331943
dc.description.abstractThe presymptomatic stages of frontotemporal dementia (FTD) are still poorly defined and encompass a long accrual of progressive biological (preclinical) and then clinical (prodromal) changes, antedating the onset of dementia. The heterogeneity of clinical presentations and the different neuropathological phenotypes have prevented a prior clear description of either preclinical or prodromal FTD. Recent advances in therapeutic approaches, at least in monogenic disease, demand a proper definition of these predementia stages. It has become clear that a consensus lexicon is needed to comprehensively describe the stages that anticipate dementia. The goal of the present work is to review existing literature on the preclinical and prodromal phases of FTD, providing recommendations to address the unmet questions, therefore laying out a strategy for operationalizing and better characterizing these presymptomatic disease stages.
dc.format.mediumPrint-Electronic
dc.publisherWiley
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectdefinition
dc.subjectfrontotemporal dementia
dc.subjectfrontotemporal lobar degeneration
dc.subjectmild cognitive and/or behavioral and/or motor impairment
dc.subjectmild cognitive impairment
dc.subjectpreclinical
dc.subjectpresymptomatic
dc.subjectprodromal
dc.titleConceptual framework for the definition of preclinical and prodromal frontotemporal dementia.
dc.typeArticle
dc.publisher.departmentDepartment of Clinical Neurosciences
dc.date.updated2021-12-24T12:00:06Z
prism.publicationDate2021
prism.publicationNameAlzheimers Dement
dc.identifier.doi10.17863/CAM.79392
dcterms.dateAccepted2021-08-30
rioxxterms.versionofrecord10.1002/alz.12485
rioxxterms.versionVoR
dc.contributor.orcidRowe, James [0000-0001-7216-8679]
dc.identifier.eissn1552-5279
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMRC (unknown)
cam.issuedOnline2021-12-07
cam.depositDate2021-12-24
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International