Long-term effects on the child of near-term glucocorticoids in the fetus.
Arch Dis Child Fetal Neonatal Ed
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Shreeve, N., & Smith, G. C. (2022). Long-term effects on the child of near-term glucocorticoids in the fetus.. Arch Dis Child Fetal Neonatal Ed https://doi.org/10.1136/archdischild-2021-323090
The human fetal hypothalamic-pituitary axis (HPA) becomes activated as pregnancy advances towards term. This critical developmental trigger occurs in most mammalian species and results in a fetal adrenal glucocorticoid (GC) surge essential for lung maturation. In addition, HPA activation also contributes to parturition and the maturation of other fetal organs. Precocious activation of GC receptors can be induced by endogenous cortisol release in response to fetal exposure to an adverse intrauterine environment, or when synthetic glucocorticoids are administered to the mother during pregnancy (antenatal maternal glucocorticoid, AMGC).
External DOI: https://doi.org/10.1136/archdischild-2021-323090
This record's URL: https://www.repository.cam.ac.uk/handle/1810/331953
Attribution-NonCommercial 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc/4.0/