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dc.contributor.authorCOVID-19 Host Genetics Initiative
dc.date.accessioned2022-01-05T10:49:24Z
dc.date.available2022-01-05T10:49:24Z
dc.date.issued2021-12
dc.date.submitted2021-03-02
dc.identifier.issn0028-0836
dc.identifier.others41586-021-03767-x
dc.identifier.other3767
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332007
dc.description.abstractThe genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3-7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectArticle
dc.subject/631/208
dc.subject/631/208/205/2138
dc.subject/631/326/596/4130
dc.subject/692/699/255/2514
dc.subject/45/43
dc.subjectarticle
dc.titleMapping the human genetic architecture of COVID-19.
dc.typeArticle
dc.date.updated2022-01-05T10:49:09Z
prism.endingPage477
prism.issueIdentifier7889
prism.publicationNameNature
prism.startingPage472
prism.volume600
dc.identifier.doi10.17863/CAM.79455
dcterms.dateAccepted2021-06-23
rioxxterms.versionofrecord10.1038/s41586-021-03767-x
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidNeale, Benjamin M. [0000-0003-1513-6077]
dc.identifier.eissn1476-4687
pubs.funder-project-idMedical Research Council (MR/P011705/1)
cam.issuedOnline2021-07-08


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