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dc.contributor.authorMatuleviciute, Rugile
dc.contributor.authorCunha, Pedro P
dc.contributor.authorJohnson, Randall
dc.contributor.authorFoskolou, Iosifina
dc.date.accessioned2022-01-05T16:29:26Z
dc.date.available2022-01-05T16:29:26Z
dc.date.issued2021-12
dc.date.submitted2020-10-29
dc.identifier.issn1742-464X
dc.identifier.otherfebs15695
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332049
dc.description.abstractHypoxia has a significant impact on many physiological and pathological processes. Over the recent years, its role in modulation of epigenetic remodelling has also become clearer. In cancer, low oxygen environments and aberrant epigenomes often go hand in hand, and changes in DNA methylation are now commonly recognised as potential outcome indicators. TET (ten-eleven translocation) family enzymes are alpha-ketoglutarate-, iron- and oxygen-dependent DNA demethylases and are key players in these processes. Although TETs have historically been considered tumour suppressors, recent studies suggest that their functions in cancer might not be straightforward. Recently, inhibition of TETs has been reported to have positive impact in cancer immunotherapy and vaccination studies. This underlines the current interest in developing targeted pharmaceutical inhibitors of these enzymes. Here, we will survey the complexity of TET roles in cancer, and its hypoxic modulation, as well as highlight the potential of these enzymes as therapeutic targets.
dc.languageen
dc.publisherWiley
dc.subjectReview Article
dc.subjectReview Articles
dc.subject5hmC
dc.subjectcancer
dc.subjecthypoxia
dc.subjectimmunotherapy
dc.subjectTET
dc.subjectα‐KG‐dependent enzymes
dc.titleOxygen regulation of TET enzymes.
dc.typeArticle
dc.date.updated2022-01-05T16:29:25Z
prism.endingPage7161
prism.issueIdentifier24
prism.publicationNameFEBS J
prism.startingPage7143
prism.volume288
dc.identifier.doi10.17863/CAM.79496
dcterms.dateAccepted2021-01-04
rioxxterms.versionofrecord10.1111/febs.15695
rioxxterms.versionAO
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidJohnson, Randall [0000-0002-4084-6639]
dc.contributor.orcidFoskolou, Iosifina [0000-0003-1874-6356]
dc.identifier.eissn1742-4658
pubs.funder-project-idWellcome Trust (214283/Z/18/Z)
cam.issuedOnline2021-01-29


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