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dc.contributor.authorWang, Ling
dc.contributor.authorCheng, Qiantao
dc.contributor.authorPeng, Min
dc.contributor.authorLv, Daping
dc.contributor.authorZi, Wenjie
dc.contributor.authorXu, Gelin
dc.contributor.authorLiu, Xinfeng
dc.date.accessioned2022-01-06T11:50:22Z
dc.date.available2022-01-06T11:50:22Z
dc.date.issued2020-10
dc.identifier.issn2095-5138
dc.identifier.otherPMC8288456
dc.identifier.other34691605
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332153
dc.description.abstractBACKGROUND AND PURPOSE: The predictive effect of blood cell ratio on ischemic event has been widely confirmed. Whether PWR and PNR can assess the risk of endovascular treatment (EVT) is largely unclear. This study aimed to investigate the prognostic value of PNR and PWR in acute ischemic stroke patients treated with EVT. METHODS: Poor functional outcome was defined as Modified Rankin Scale (mRS) of 3-6 at 3 months, Symptomatic intracranial hemorrhage (sICH) was diagnosed based on CT scan and classified according to the criterial of Heidelberg Bleeding Classification. Binary logistical regression was used to analyze the relationship of PWR, PNR with functional outcome and symptomatic intracranial hemorrhage (sICH). RESULTS: Patients with good prognosis had higher PNR and PWR value (29 vs. 24, P=0.002) (22 vs. 19, P=0.009), a lower rate of sICH (2.9% vs. 24.9%, P<0.001). In model 1, the lower PNR significantly associated with poor functional outcome (OR, 0.48; 95% CI 0.26-0.88; P=0.018), and sICH (OR, 0.42; 95% CI 0.19-0.91; P=0.028). The lower PWR only significantly associated with poor prognosis (OR, 0.97; 95% CI 0.94-1.00; P=0.038), and had a trend relation with sICH (OR, 0.98; 95% CI 0.94-1.02; P=0.328). In model 2 lower PNR still significantly associated with poor functional outcome (OR, 0.53; 95% CI 0.29-0.99; P=0.047), but showed a trend for predicting sICH (OR, 0.56; 95% CI 0.25-1.25; P=0.158). CONCLUSION: Platelet to leukocyte ratio may be use to assess the risk of functional outcome and sICH in patients with acute anterior circulation occlusion stroke undergoing endovascular treatment in real world China.
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2053-714X
dc.sourcenlmid: 101633095
dc.subjectCell Surface Engineering
dc.subjectProtein Internalization
dc.subjectThiol-functionalization
dc.subjectHarsh Condition Resistance
dc.subjectHigh Photosynthetic Ability
dc.subjectOrdered Colloidal Packing
dc.titleThe relationship between the platelet to leukocyte ratio and mechanical thrombectomy outcomes in acute ischemic stroke patients.
dc.typeArticle
dc.date.updated2022-01-06T11:50:21Z
prism.issueIdentifier4
prism.publicationNameNeurol Res
prism.volume8
dc.identifier.doi10.17863/CAM.79599
rioxxterms.versionofrecord10.1080/01616412.2020.1790868
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidLiu, Xinfeng [0000-0002-8182-9632]
dc.identifier.eissn1743-1328
cam.issuedOnline2020-05-09


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International