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dc.contributor.authorKilo, Lukas
dc.contributor.authorStürner, Tomke
dc.contributor.authorTavosanis, Gaia
dc.contributor.authorZiegler, Anna B
dc.date.accessioned2022-01-06T11:50:39Z
dc.date.available2022-01-06T11:50:39Z
dc.date.issued2021-10-16
dc.identifier.issn2073-4409
dc.identifier.otherPMC8534399
dc.identifier.other34685757
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332156
dc.description.abstractNeuronal dendrites receive, integrate, and process numerous inputs and therefore serve as the neuron's "antennae". Dendrites display extreme morphological diversity across different neuronal classes to match the neuron's specific functional requirements. Understanding how this structural diversity is specified is therefore important for shedding light on information processing in the healthy and diseased nervous system. Popular models for in vivo studies of dendrite differentiation are the four classes of dendritic arborization (c1da-c4da) neurons of Drosophila larvae with their class-specific dendritic morphologies. Using da neurons, a combination of live-cell imaging and computational approaches have delivered information on the distinct phases and the time course of dendrite development from embryonic stages to the fully developed dendritic tree. With these data, we can start approaching the basic logic behind differential dendrite development. A major role in the definition of neuron-type specific morphologies is played by dynamic actin-rich processes and the regulation of their properties. This review presents the differences in the growth programs leading to morphologically different dendritic trees, with a focus on the key role of actin modulatory proteins. In addition, we summarize requirements and technological progress towards the visualization and manipulation of such actin regulators in vivo.
dc.languageeng
dc.publisherMDPI AG
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2073-4409
dc.sourcenlmid: 101600052
dc.subjectActin
dc.subjectTime-lapse Imaging
dc.subjectNeuronal Dendrites
dc.subjectDendrite Arborization (Da) Neurons
dc.titleDrosophila Dendritic Arborisation Neurons: Fantastic Actin Dynamics and Where to Find Them.
dc.typeArticle
dc.date.updated2022-01-06T11:50:38Z
prism.issueIdentifier10
prism.publicationNameCells
prism.volume10
dc.identifier.doi10.17863/CAM.79602
dcterms.dateAccepted2021-10-12
rioxxterms.versionofrecord10.3390/cells10102777
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidKilo, Lukas [0000-0002-2787-044X]
dc.contributor.orcidStürner, Tomke [0000-0003-4054-0784]
dc.contributor.orcidTavosanis, Gaia [0000-0002-8679-5515]
dc.identifier.eissn2073-4409
pubs.funder-project-idDFG (Teilprojekt SPP1464 to G.T. and DFG project Nr. ZI-1690/2-1 to A.B.Z.)
cam.issuedOnline2021-10-16


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International