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dc.contributor.authorSelamoglu, Ayla
dc.contributor.authorLangley, Christelle
dc.contributor.authorCrean, Rebecca
dc.contributor.authorSavulich, George
dc.contributor.authorCormack, Francesca
dc.contributor.authorSahakian, Barbara
dc.contributor.authorMason, Barbara
dc.identifier.citationJournal of psychopharmacology (Oxford, England), volume 35, issue 11, page 1349-1355
dc.descriptionFunder: NIHR MedTech
dc.descriptionFunder: in vitro diagnostic Co-operative
dc.descriptionFunder: nihr cambridge biomedical research centre
dc.descriptionFunder: Wallitt Foundation and Eton College
dc.descriptionFunder: Wellcome Trust Collaborative Award
dc.description.abstractBACKGROUND AND AIMS: Cannabis is a commonly used recreational drug in young adults. The worldwide prevalence in 18- to 25-year-olds is approximately 35%. Significant differences in cognitive performance have been reported previously for groups of cannabis users. However, the groups are often heterogeneous in terms of cannabis use. Here, we study daily cannabis users with a confirmed diagnosis of cannabis use disorder (CUD) to examine cognitive performance on measures of memory, executive function and risky decision-making. METHODS: Forty young adult daily cannabis users with diagnosed CUD and 20 healthy controls matched for sex and premorbid intelligence quotient (IQ) were included. The neuropsychological battery implemented was designed to measure multiple modes of memory (visual, episodic and working memory), risky decision-making and other domains of executive function using subtests from the Cambridge Neuropsychological Test Automated Battery (CANTAB). RESULTS: Our results showed that young adult daily cannabis users with CUD perform significantly poorer on tasks of visual and episodic memory compared with healthy controls. In addition, executive functioning was associated with the age of onset. CONCLUSIONS: Further research is required to determine whether worse performance in cognition results in cannabis use or is a consequence of cannabis use. Chronic heavy cannabis use during a critical period of brain development may have a particularly negative impact on cognition. Research into the persistence of cognitive differences and how they relate to functional outcomes such as academic/career performance is required.
dc.publisherSAGE Publications
dc.rightsAttribution 4.0 International
dc.sourceessn: 1461-7285
dc.sourcenlmid: 8907828
dc.subjectCannabis Use Disorder
dc.titleNeuropsychological performance in young adults with cannabis use disorder.
prism.publicationNameJ Psychopharmacol
dc.contributor.orcidLangley, Christelle [0000-0001-5061-2820]
dc.contributor.orcidCormack, Francesca [0000-0002-4413-177X]
dc.contributor.orcidSahakian, Barbara [0000-0001-7352-1745]
pubs.funder-project-idnational institute on drug abuse (DA026758)
pubs.funder-project-idNIDA NIH HHS (R01 DA026758)
pubs.funder-project-idWellcome Trust (200181/Z/15/Z)

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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International