Show simple item record

dc.contributor.authorFerhati, Xhenti
dc.contributor.authorSalas-Cubero, Marina
dc.contributor.authorGarrido, Pablo
dc.contributor.authorGarcía-Sanmartín, Josune
dc.contributor.authorGuerreiro, Ana
dc.contributor.authorAvenoza, Alberto
dc.contributor.authorBusto, Jesús H
dc.contributor.authorPeregrina, Jesús M
dc.contributor.authorMartínez, Alfredo
dc.contributor.authorJiménez-Moreno, Ester
dc.contributor.authorBernardes, Gonçalo JL
dc.contributor.authorCorzana, Francisco
dc.date.accessioned2022-01-06T11:51:09Z
dc.date.available2022-01-06T11:51:09Z
dc.date.issued2021-11-05
dc.identifier.issn1523-7060
dc.identifier.otherPMC8576835
dc.identifier.other34694118
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332164
dc.description.abstractA self-immolative bioorthogonal conditionally cleavable linker based on Grob fragmentation is described. It is derived from 1,3-aminocyclohexanols and allows the release of sulfonate-containing compounds in aqueous media. Modulation of the amine pKa promotes fragmentation even at slightly acidic pH, a common feature of several tumor environments. The Grob fragmentation can also occur under physiological conditions in living cells, highlighting the potential bioorthogonal applicability of this reaction.
dc.languageeng
dc.publisherAmerican Chemical Society (ACS)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 1523-7052
dc.sourcenlmid: 100890393
dc.titleBioorthogonal Self-Immolative Linker Based on Grob Fragmentation.
dc.typeArticle
dc.date.updated2022-01-06T11:51:09Z
prism.endingPage8584
prism.issueIdentifier21
prism.publicationNameOrg Lett
prism.startingPage8580
prism.volume23
dc.identifier.doi10.17863/CAM.79610
dcterms.dateAccepted2021-10-22
rioxxterms.versionofrecord10.1021/acs.orglett.1c03299
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidGarrido, Pablo [0000-0002-5960-8569]
dc.contributor.orcidGarcía-Sanmartín, Josune [0000-0003-4391-5537]
dc.contributor.orcidBusto, Jesús H [0000-0003-4403-4790]
dc.contributor.orcidPeregrina, Jesús M [0000-0003-3778-7065]
dc.contributor.orcidMartínez, Alfredo [0000-0003-4882-4044]
dc.contributor.orcidJiménez-Moreno, Ester [0000-0002-5045-433X]
dc.contributor.orcidBernardes, Gonçalo JL [0000-0001-6594-8917]
dc.contributor.orcidCorzana, Francisco [0000-0001-5597-8127]
dc.identifier.eissn1523-7052
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (675007)
cam.issuedOnline2021-10-25


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International