Bioorthogonal Self-Immolative Linker Based on Grob Fragmentation.
dc.contributor.author | Ferhati, Xhenti | |
dc.contributor.author | Salas-Cubero, Marina | |
dc.contributor.author | Garrido, Pablo | |
dc.contributor.author | García-Sanmartín, Josune | |
dc.contributor.author | Guerreiro, Ana | |
dc.contributor.author | Avenoza, Alberto | |
dc.contributor.author | Busto, Jesús H | |
dc.contributor.author | Peregrina, Jesús M | |
dc.contributor.author | Martínez, Alfredo | |
dc.contributor.author | Jiménez-Moreno, Ester | |
dc.contributor.author | Lopes Bernardes, Goncalo | |
dc.contributor.author | Corzana, Francisco | |
dc.date.accessioned | 2022-01-06T11:51:09Z | |
dc.date.available | 2022-01-06T11:51:09Z | |
dc.date.issued | 2021-11-05 | |
dc.identifier.issn | 1523-7060 | |
dc.identifier.other | PMC8576835 | |
dc.identifier.other | 34694118 | |
dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/332164 | |
dc.description.abstract | A self-immolative bioorthogonal conditionally cleavable linker based on Grob fragmentation is described. It is derived from 1,3-aminocyclohexanols and allows the release of sulfonate-containing compounds in aqueous media. Modulation of the amine pKa promotes fragmentation even at slightly acidic pH, a common feature of several tumor environments. The Grob fragmentation can also occur under physiological conditions in living cells, highlighting the potential bioorthogonal applicability of this reaction. | |
dc.language | eng | |
dc.publisher | American Chemical Society (ACS) | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | essn: 1523-7052 | |
dc.source | nlmid: 100890393 | |
dc.title | Bioorthogonal Self-Immolative Linker Based on Grob Fragmentation. | |
dc.type | Article | |
dc.date.updated | 2022-01-06T11:51:09Z | |
prism.endingPage | 8584 | |
prism.issueIdentifier | 21 | |
prism.publicationName | Org Lett | |
prism.startingPage | 8580 | |
prism.volume | 23 | |
dc.identifier.doi | 10.17863/CAM.79610 | |
dcterms.dateAccepted | 2021-10-22 | |
rioxxterms.versionofrecord | 10.1021/acs.orglett.1c03299 | |
rioxxterms.version | VoR | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.contributor.orcid | Garrido, Pablo [0000-0002-5960-8569] | |
dc.contributor.orcid | García-Sanmartín, Josune [0000-0003-4391-5537] | |
dc.contributor.orcid | Busto, Jesús H [0000-0003-4403-4790] | |
dc.contributor.orcid | Peregrina, Jesús M [0000-0003-3778-7065] | |
dc.contributor.orcid | Martínez, Alfredo [0000-0003-4882-4044] | |
dc.contributor.orcid | Jiménez-Moreno, Ester [0000-0002-5045-433X] | |
dc.contributor.orcid | Lopes Bernardes, Goncalo [0000-0001-6594-8917] | |
dc.contributor.orcid | Corzana, Francisco [0000-0001-5597-8127] | |
dc.identifier.eissn | 1523-7052 | |
pubs.funder-project-id | European Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (675007) | |
cam.issuedOnline | 2021-10-25 |
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