Show simple item record

dc.contributor.authorSheekey, Eleanor
dc.contributor.authorNarita, Masashi
dc.date.accessioned2022-01-06T12:53:42Z
dc.date.available2022-01-06T12:53:42Z
dc.date.issued2021-12-17
dc.date.submitted2021-10-09
dc.identifier.issn1742-464X
dc.identifier.otherfebs16325
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332187
dc.description.abstractThe tumour suppressor p53, a stress-responsive transcription factor, plays a central role in cellular senescence. The role of p53 in senescence-associated stable proliferative arrest has been extensively studied. However, increasing evidence indicates that p53 also modulates the ability of senescent cells to produce and secrete diverse bioactive factors (collectively called the senescence-associated secretory phenotype, SASP). Senescence has been linked with both physiological and pathological conditions, the latter including ageing, cancer and other age-related disorders, in part through the SASP. Cellular functions are generally dictated by the expression profile of lineage-specific genes. Indeed, expression of SASP factors and their regulators are often biased by cell type. In addition, emerging evidence suggests that p53 contributes to deregulation of more stringent lineage-specific genes during senescence. P53 itself is also tightly regulated at the protein level. In contrast to the rapid and transient activity of p53 upon stress ('acute-p53'), during senescence and other prolonged pathological conditions, p53 activities are sustained and fine-tuned through a combination of different inputs and outputs ('chronic-p53').
dc.languageen
dc.publisherWiley
dc.subjectReview Article
dc.subjectReview Articles
dc.subjectDNA damage response
dc.subjectp53
dc.subjectSASP
dc.subjectsenescence
dc.subjecttranscription
dc.titlep53 in senescence - it's a marathon not a sprint.
dc.typeArticle
dc.date.updated2022-01-06T12:53:41Z
prism.publicationNameFEBS J
dc.identifier.doi10.17863/CAM.79633
dcterms.dateAccepted2021-12-15
rioxxterms.versionofrecord10.1111/febs.16325
rioxxterms.versionAO
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidSheekey, Eleanor [0000-0002-1501-550X]
dc.contributor.orcidNarita, Masashi [0000-0001-7764-577X]
dc.identifier.eissn1742-4658
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/S013466/1)
pubs.funder-project-idBBSRC (BB/T013486/1)
cam.issuedOnline2021-12-26


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record