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dc.contributor.authorBaxendale, Helen E
dc.contributor.authorWells, David
dc.contributor.authorGronlund, Jessica
dc.contributor.authorNadesalingham, Angalee
dc.contributor.authorPaloniemi, Mina
dc.contributor.authorCarnell, George
dc.contributor.authorTonks, Paul
dc.contributor.authorCeron-Gutierrez, Lourdes
dc.contributor.authorEbrahimi, Soraya
dc.contributor.authorSayer, Ashleigh
dc.contributor.authorBriggs, John AG
dc.contributor.authorZiong, Xiaoli
dc.contributor.authorNathan, James
dc.contributor.authorGrice, Guinevere
dc.contributor.authorJames, Leo C
dc.contributor.authorLuptak, Jakub
dc.contributor.authorPai, Sumita
dc.contributor.authorHeeney, Jonathan
dc.contributor.authorLear, Sara
dc.contributor.authorDoffinger, Rainer
dc.date.accessioned2022-01-06T12:55:18Z
dc.date.available2022-01-06T12:55:18Z
dc.date.issued2021-07
dc.identifier.issn2393-1809
dc.identifier.otherPMC8519390
dc.identifier.other34722923
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332205
dc.description.abstractINTRODUCTION: In early 2020, at first surge of the coronavirus disease 2019 (COVID-19) pandemic, many health care workers (HCW) were re-deployed to critical care environments to support intensive care teams looking after patients with severe COVID-19. There was considerable anxiety of increased risk of COVID-19 for these staff. To determine whether critical care HCW were at increased risk of hospital acquired infection, we explored the relationship between workplace, patient facing role and evidence of immune exposure to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within a quaternary hospital providing a regional critical care response. Routine viral surveillance was not available at this time. METHODS: We screened over 500 HCW (25% of the total workforce) for history of clinical symptoms of possible COVID19, assigning a symptom severity score, and quantified SARS-CoV-2 serum antibodies as evidence of immune exposure to the virus. RESULTS: Whilst 45% of the cohort reported symptoms that they consider may have represented COVID-19, 14% had evidence of immune exposure. Staffs in patient facing critical care roles were least likely to be seropositive (9%) and staff working in non-patient facing roles most likely to be seropositive (22%). Anosmia and fever were the most discriminating symptoms for seropositive status. Older males presented with more severe symptoms. Of the 12 staff screened positive by nasal swab (10 symptomatic), 3 showed no evidence of seroconversion in convalescence. CONCLUSIONS: Patient facing staff working in critical care do not appear to be at increased risk of hospital acquired infection however the risk of nosocomial infection from non-patient facing staff may be more significant than previous recognised. Most symptoms ascribed to possible COVID-19 were found to have no evidence of immune exposure however seroprevalence may underrepresent infection frequency. Older male staff were at the greatest risk of more severe symptoms.
dc.languageeng
dc.publisherWalter de Gruyter GmbH
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceessn: 2393-1817
dc.sourcenlmid: 101706934
dc.subjectHealth care workers
dc.subjectCritical Care
dc.subjectSeroprevalence
dc.subjectCovid-19
dc.subjectSars-cov-2
dc.titleCritical Care Workers Have Lower Seroprevalence of SARS-CoV-2 IgG Compared with Non-patient Facing Staff in First Wave of COVID19.
dc.typeArticle
dc.date.updated2022-01-06T12:55:17Z
prism.endingPage210
prism.issueIdentifier3
prism.publicationNameJ Crit Care Med (Targu Mures)
prism.startingPage199
prism.volume7
dc.identifier.doi10.17863/CAM.79651
dcterms.dateAccepted2021-05-28
rioxxterms.versionofrecord10.2478/jccm-2021-0018
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.contributor.orcidCarnell, George [0000-0001-8875-0989]
dc.contributor.orcidTonks, Paul [0000-0003-3512-5631]
dc.contributor.orcidNathan, James [0000-0002-0248-1632]
dc.contributor.orcidHeeney, Jonathan [0000-0003-2702-1621]
dc.identifier.eissn2393-1817
pubs.funder-project-idLister Institute of Preventive Medicine (unknown)
pubs.funder-project-idWellcome Trust (215477/Z/19/Z)
cam.issuedOnline2021-08-05


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International