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dc.contributor.authorSlob, Eric AW
dc.contributor.authorRietveld, Cornelius A
dc.date.accessioned2022-01-06T12:55:56Z
dc.date.available2022-01-06T12:55:56Z
dc.date.issued2021
dc.identifier.issn1932-6203
dc.identifier.otherPMC8570524
dc.identifier.other34739507
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332215
dc.description.abstractBACKGROUND: Tobacco consumption is one of the leading causes of preventable death. In this study, we analyze whether someone's genetic predisposition to smoking moderates the response to tobacco excise taxes. METHODS: We interact polygenic scores for smoking behavior with state-level tobacco excise taxes in longitudinal data (1992-2016) from the US Health and Retirement Study (N = 12,058). RESULTS: Someone's genetic propensity to smoking moderates the effect of tobacco excise taxes on smoking behavior along the extensive margin (smoking vs. not smoking) and the intensive margin (the amount of tobacco consumed). In our analysis sample, we do not find a significant gene-environment interaction effect on smoking cessation. CONCLUSIONS: When tobacco excise taxes are relatively high, those with a high genetic predisposition to smoking are less likely (i) to smoke, and (ii) to smoke heavily. While tobacco excise taxes have been effective in reducing smoking, the gene-environment interaction effects we observe in our sample suggest that policy makers could benefit from taking into account the moderating role of genes in the design of future tobacco control policies.
dc.languageeng
dc.publisherPublic Library of Science (PLoS)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 1932-6203
dc.sourcenlmid: 101285081
dc.titleGenetic predispositions moderate the effectiveness of tobacco excise taxes.
dc.typeArticle
dc.date.updated2022-01-06T12:55:55Z
prism.issueIdentifier11
prism.publicationNamePLoS One
prism.volume16
dc.identifier.doi10.17863/CAM.79661
dcterms.dateAccepted2021-10-06
rioxxterms.versionofrecord10.1371/journal.pone.0259210
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidSlob, Eric AW [0000-0002-1644-0735]
dc.identifier.eissn1932-6203
pubs.funder-project-idWellcome Trust (204623/Z/16/Z)
pubs.funder-project-idMedical Research Council (MC_UU_00002/7)
cam.issuedOnline2021-11-05


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International