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dc.contributor.authorFillmore, Nathanael
dc.contributor.authorBell, Steven
dc.contributor.authorShen, Ciyue
dc.contributor.authorNguyen, Vinh
dc.contributor.authorLa, Jennifer
dc.contributor.authorDubreuil, Maureen
dc.contributor.authorStrymish, Judith
dc.contributor.authorBrophy, Mary
dc.contributor.authorMehta, Gautam
dc.contributor.authorWu, Hao
dc.contributor.authorLieberman, Judy
dc.contributor.authorDo, Nhan
dc.contributor.authorSander, Chris
dc.date.accessioned2022-01-06T12:56:08Z
dc.date.available2022-01-06T12:56:08Z
dc.date.issued2021
dc.identifier.issn1932-6203
dc.identifier.otherPMC8553043
dc.identifier.other34710137
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332217
dc.descriptionFunder: British Heart Foundation
dc.descriptionFunder: VA Boston Healthcare System
dc.descriptionFunder: Dana-Farber Cancer Institute
dc.descriptionFunder: VA Cooperative Studies Program
dc.descriptionFunder: National Institutes of Health
dc.descriptionFunder: Harvard Medical School
dc.description.abstractEffective, low-cost therapeutics are needed to prevent and treat COVID-19. Severe COVID-19 disease is linked to excessive inflammation. Disulfiram is an approved oral drug used to treat alcohol use disorder that is a potent anti-inflammatory agent and an inhibitor of the viral proteases. We investigated the potential effects of disulfiram on SARS-CoV-2 infection and disease severity in an observational study using a large database of clinical records from the national US Veterans Affairs healthcare system. A multivariable Cox regression adjusted for demographic information and diagnosis of alcohol use disorder revealed a reduced risk of SARS-CoV-2 infection with disulfiram use at a hazard ratio of 0.66 (34% lower risk, 95% confidence interval 24-43%). There were no COVID-19 related deaths among the 188 SARS-CoV-2 positive patients treated with disulfiram, in contrast to 5-6 statistically expected deaths based on the untreated population (P = 0.03). Our epidemiological results suggest that disulfiram may contribute to the reduced incidence and severity of COVID-19. These results support carefully planned clinical trials to assess the potential therapeutic effects of disulfiram in COVID-19.
dc.languageeng
dc.publisherPublic Library of Science (PLoS)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 1932-6203
dc.sourcenlmid: 101285081
dc.subjectHumans
dc.subjectAlcoholism
dc.subjectDisulfiram
dc.subjectSeverity of Illness Index
dc.subjectProportional Hazards Models
dc.subjectRisk Factors
dc.subjectRetrospective Studies
dc.subjectCohort Studies
dc.subjectAdult
dc.subjectMiddle Aged
dc.subjectVeterans
dc.subjectFemale
dc.subjectMale
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.titleDisulfiram use is associated with lower risk of COVID-19: A retrospective cohort study.
dc.typeArticle
dc.date.updated2022-01-06T12:56:07Z
prism.issueIdentifier10
prism.publicationNamePLoS One
prism.volume16
dc.identifier.doi10.17863/CAM.79663
dcterms.dateAccepted2021-10-11
rioxxterms.versionofrecord10.1371/journal.pone.0259061
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidFillmore, Nathanael [0000-0002-8058-3423]
dc.contributor.orcidBell, Steven [0000-0001-6774-3149]
dc.contributor.orcidShen, Ciyue [0000-0002-5416-2481]
dc.contributor.orcidLa, Jennifer [0000-0003-2266-0221]
dc.contributor.orcidMehta, Gautam [0000-0002-5696-359X]
dc.contributor.orcidWu, Hao [0000-0002-7281-8579]
dc.contributor.orcidLieberman, Judy [0000-0002-6200-4715]
dc.contributor.orcidDo, Nhan [0000-0001-6868-7011]
dc.contributor.orcidSander, Chris [0000-0001-6059-6270]
dc.identifier.eissn1932-6203
pubs.funder-project-idNational Institute of Arthritis and Musculoskeletal and Skin Disease (K23AR069127)
pubs.funder-project-idNIAMS NIH HHS (K23 AR069127)
pubs.funder-project-idNICHD NIH HHS (DP1 HD087988)
pubs.funder-project-idbritish heart foundation (RG/4/32218)
cam.issuedOnline2021-10-28


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International