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Genetically Predicted Neutrophil-to-Lymphocyte Ratio and Coronary Artery Disease: Evidence From Mendelian Randomization.
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Peer-reviewed
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Abstract
Inflammation contributes to atherosclerosis and coronary artery disease (CAD). In order to help identify therapeutic targets, it is important to ascertain whether biomarkers associated with CAD risk are causal. In a recent meta-analysis of clinical trials, neutrophil-to lymphocyte ratio (NLR) was associated with increased cardiovascular risk 1 . We investigate a potential causal nature of this relationship by performing Mendelian randomization (MR) analyses
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Circ Genom Precis Med
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2574-8300
2574-8300
2574-8300
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Ovid Technologies (Wolters Kluwer Health)
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Wellcome Trust (204623/Z/16/Z)