Show simple item record

dc.contributor.authorPavel, Mariana
dc.contributor.authorTanasa, Radu
dc.contributor.authorPark, Sojung
dc.contributor.authorRubinsztein, David
dc.date.accessioned2022-01-07T00:31:14Z
dc.date.available2022-01-07T00:31:14Z
dc.date.issued2022-01-14
dc.identifier.issn0265-9247
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332255
dc.description.abstractAutophagy and YAP1-WWTR1/TAZ signalling are tightly linked in a complex control system of forward and feedback pathways which determine different cellular outcomes in differing cell types at different time-points after perturbations. Here we extend our previous experimental and modelling approaches to consider two possibilities. First, we have performed additional mathematical modelling to explore how the autophagy-YAP1 crosstalk may be controlled by posttranslational modifications of components of the pathways. Second, since analogous contrasting results have also been reported for autophagy as a regulator of other transduction pathways engaged in tumorigenesis (Wnt/β-catenin, TGF-β/Smads, NF-kB or XIAP/cIAPs), we have considered if such discrepancies may be explicable through situations involving competing pathways and feedback loops in different cell types, analogous to the autophagy-YAP/TAZ situation. Since distinct posttranslational modifications dominate those pathways in distinct cells, these need to be understood to enable appropriate cell type-specific therapeutic strategies for cancers and other diseases.
dc.description.sponsorshipWe are grateful for funding from the UK Dementia Research Institute (funded by MRC, Alzheimer’s Research UK and the Alzheimer’s Society), a grant of the Romanian Ministry of Research, Innovation and Digitization, CNCS/CCCDI-UEFISCDI, project number PN-III-P1-1.1-PD-2019-0733, within PNCDI-III, and POC/448/1/1/127606 CENEMED project (M.P.).
dc.publisherWiley
dc.rightsAll Rights Reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleThe complexity of biological control systems: An autophagy case study.
dc.typeArticle
dc.publisher.departmentDepartment of Medical Genetics
dc.date.updated2022-01-06T09:09:32Z
prism.publicationNameBioessays
dc.identifier.doi10.17863/CAM.79700
dcterms.dateAccepted2022-01-04
rioxxterms.versionofrecord10.1002/bies.202100224
rioxxterms.versionAM
dc.contributor.orcidRubinsztein, David [0000-0001-5002-5263]
dc.identifier.eissn1521-1878
rioxxterms.typeJournal Article/Review
cam.issuedOnline2022-01-14
cam.orpheus.successTue Feb 01 19:02:37 GMT 2022 - Embargo updated
cam.depositDate2022-01-06
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2023-01-14


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record