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dc.contributor.authorMacKenzie, Georgina
dc.contributor.authorSubramaniam, Sumithra
dc.contributor.authorCaldwell, Lindsey J
dc.contributor.authorFitzgerald, Denise
dc.contributor.authorHarrison, Neil A
dc.contributor.authorHong, Soyon
dc.contributor.authorIrani, Sarosh R
dc.contributor.authorKhandaker, Golam
dc.contributor.authorListon, Adrian
dc.contributor.authorMiron, Veronique E
dc.contributor.authorMondelli, Valeria
dc.contributor.authorMorgan, B Paul
dc.contributor.authorPariante, Carmine
dc.contributor.authorShah, Divya K
dc.contributor.authorTaams, Leonie S
dc.contributor.authorTeeling, Jessica L
dc.contributor.authorUpthegrove, Rachel
dc.date.accessioned2022-01-07T10:41:09Z
dc.date.available2022-01-07T10:41:09Z
dc.date.issued2021
dc.identifier.issn2398-502X
dc.identifier.otherPMC8558843
dc.identifier.other34778569
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332279
dc.description.abstractNeuroimmunology in the broadest sense is the study of interactions between the nervous and the immune systems. These interactions play important roles in health from supporting neural development, homeostasis and plasticity to modifying behaviour. Neuroimmunology is increasingly recognised as a field with the potential to deliver a significant positive impact on human health and treatment for neurological and psychiatric disorders. Yet, translation to the clinic is hindered by fundamental knowledge gaps on the underlying mechanisms of action or the optimal timing of an intervention, and a lack of appropriate tools to visualise and modulate both systems. Here we propose ten key disease-agnostic research questions that, if addressed, could lead to significant progress within neuroimmunology in the short to medium term. We also discuss four cross-cutting themes to be considered when addressing each question: i) bi-directionality of neuroimmune interactions; ii) the biological context in which the questions are addressed (e.g. health vs disease vs across the lifespan); iii) tools and technologies required to fully answer the questions; and iv) translation into the clinic. We acknowledge that these ten questions cannot represent the full breadth of gaps in our understanding; rather they focus on areas which, if addressed, may have the most broad and immediate impacts. By defining these neuroimmunology priorities, we hope to unite existing and future research teams, who can make meaningful progress through a collaborative and cross-disciplinary effort.
dc.languageeng
dc.publisherF1000 Research Ltd
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2398-502X
dc.sourcenlmid: 101696457
dc.subjectCentral nervous system
dc.subjectPeripheral nervous system
dc.subjectBehaviour
dc.subjectInflammation
dc.subjectPsychoneuroimmunology
dc.subjectMental health
dc.subjectNeuroimmune Interactions
dc.subjectImmunopsychiatry
dc.titleResearch priorities for neuroimmunology: identifying the key research questions to be addressed by 2030.
dc.typeArticle
dc.date.updated2022-01-07T10:41:08Z
prism.publicationNameWellcome Open Res
prism.volume6
dc.identifier.doi10.17863/CAM.79726
dcterms.dateAccepted2021-07-09
rioxxterms.versionofrecord10.12688/wellcomeopenres.16997.1
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidMacKenzie, Georgina [0000-0002-3389-8772]
dc.contributor.orcidCaldwell, Lindsey J [0000-0003-2229-6431]
dc.contributor.orcidHarrison, Neil A [0000-0002-9584-3769]
dc.contributor.orcidHong, Soyon [0000-0002-5744-4871]
dc.contributor.orcidIrani, Sarosh R [0000-0002-7667-9748]
dc.contributor.orcidKhandaker, Golam [0000-0002-4935-9220]
dc.contributor.orcidListon, Adrian [0000-0002-6272-4085]
dc.contributor.orcidTaams, Leonie S [0000-0002-9337-7194]
dc.contributor.orcidTeeling, Jessica L [0000-0003-4004-7391]
dc.identifier.eissn2398-502X
cam.issuedOnline2021-07-29


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International