Mental health outcomes after SARS-CoV-2 vaccination in the United States: A national cross-sectional study.
Aruldass, Athina R
Cardinal, Rudolf N
Journal of Affective Disorders
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Chen, S., Aruldass, A. R., & Cardinal, R. N. (2022). Mental health outcomes after SARS-CoV-2 vaccination in the United States: A national cross-sectional study.. Journal of Affective Disorders, 298 (Pt A), 396-399. https://doi.org/10.1016/j.jad.2021.10.134
Funder: NIHR Cambridge Biomedical Research Centre
Funder: National Institute for Health Research (NIHR)
BACKGROUND: Worsening of anxiety and depressive symptoms have been widely described during the COVID-19 pandemic. It can be hypothesized that vaccination could link to reduced symptoms of anxiety and/or depression. However, to date, no study has assessed this. This study aims to examine anxiety and depressive symptoms after vaccination in US adults, meanwhile test sociodemographic disparities in these outcomes. METHODS: Data from the January 6-June 7 2021, cross-sectional Household Pulse Survey were analyzed. Using survey-weighted logistic regression, we assessed the relationships between SARS-CoV-2 vaccination and anxiety and/or depressive symptoms, both on overall and sociodemographic subgroups. We controlled for a variety of potential socioeconomic and demographic confounding factors. RESULTS: Of the 453,167 participants studied, 52.2% of the participants had received the COVID-19 vaccine, and 26.5% and 20.3% of the participants reported anxiety and depression, respectively. Compared to those not vaccinated, the vaccinated participants had a 13% lower odds of anxiety (adjusted odds ratio [AOR] = 0.85, 95%CI 0.83-0.90) and 17% lower odds of depression (AOR = 0.83, 95%CI 0.79-0.85). Disparities on the above associations were identified in age, marital status, education level, ethnic/race, and income level, but not on gender. LIMITATIONS: The causal inference was not able to be investigated due to the cross-sectional study design. CONCLUSION: Being vaccinated for SARS-CoV-2 was associated with lower odds of anxiety and/or depressive symptoms. While those more middle-aged or more affluent, were more likely to show these negative associations, the contrary was observed in ethnic minorities and those with lower educational attainment. More strategic and demography-sensitive public health communications could perhaps temper these issues.
Depression, Anxiety, United States, Sars-Cov-2 Vaccination
Medical Research Council (MC_PC_17213)
External DOI: https://doi.org/10.1016/j.jad.2021.10.134
This record's URL: https://www.repository.cam.ac.uk/handle/1810/332323