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dc.contributor.authorWeber, Thomas
dc.contributor.authorProtogerou, Athanase D
dc.contributor.authorAgharazii, Mohsen
dc.contributor.authorArgyris, Antonis
dc.contributor.authorAoun Bahous, Sola
dc.contributor.authorBanegas, Jose R
dc.contributor.authorBinder, Ronald K
dc.contributor.authorBlacher, Jacques
dc.contributor.authorAraujo Brandao, Andréa
dc.contributor.authorCruz, Juan J
dc.contributor.authorDanninger, Kathrin
dc.contributor.authorGiannatasio, Cristina
dc.contributor.authorGraciani, Auxiliadora
dc.contributor.authorHametner, Bernhard
dc.contributor.authorJankowski, Piotr
dc.contributor.authorLi, Yan
dc.contributor.authorMaloberti, Alessandro
dc.contributor.authorMayer, Christopher C
dc.contributor.authorMcDonnell, Barry J
dc.contributor.authorMcEniery, Carmel M
dc.contributor.authorAntonio Mota Gomes, Marco
dc.contributor.authorMachado Gomes, Annelise
dc.contributor.authorLorenza Muiesan, Maria
dc.contributor.authorNemcsik, Janos
dc.contributor.authorPaini, Anna
dc.contributor.authorRodilla, Enrique
dc.contributor.authorSchutte, Aletta E
dc.contributor.authorSfikakis, Petros P
dc.contributor.authorTerentes-Printzios, Dimitrios
dc.contributor.authorVallée, Alexandre
dc.contributor.authorVlachopoulos, Charalambos
dc.contributor.authorWare, Lisa
dc.contributor.authorWilkinson, Ian
dc.contributor.authorZweiker, Robert
dc.contributor.authorSharman, James E
dc.contributor.authorWassertheurer, Siegfried
dc.contributor.authorInternational Academic 24-Hour Ambulatory Aortic Blood Pressure Consortium (i24abc.org)
dc.date.accessioned2022-01-07T16:47:03Z
dc.date.available2022-01-07T16:47:03Z
dc.date.issued2022-01
dc.identifier.citationHypertension (Dallas, Tex. : 1979), volume 79, issue 1, page 251-260
dc.identifier.issn0194-911X
dc.identifier.otherPMC8654125
dc.identifier.other34775789
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332329
dc.description.abstractCentral (aortic) systolic blood pressure (cSBP) is the pressure seen by the heart, the brain, and the kidneys. If properly measured, cSBP is closer associated with hypertension-mediated organ damage and prognosis, as compared with brachial SBP (bSBP). We investigated 24-hour profiles of bSBP and cSBP, measured simultaneously using Mobilograph devices, in 2423 untreated adults (1275 women; age, 18-94 years), free from overt cardiovascular disease, aiming to develop reference values and to analyze daytime-nighttime variability. Central SBP was assessed, using brachial waveforms, calibrated with mean arterial pressure (MAP)/diastolic BP (cSBPMAP/DBPcal), or bSBP/diastolic blood pressure (cSBPSBP/DBPcal), and a validated transfer function, resulting in 144 509 valid brachial and 130 804 valid central measurements. Averaged 24-hour, daytime, and nighttime brachial BP across all individuals was 124/79, 126/81, and 116/72 mm Hg, respectively. Averaged 24-hour, daytime, and nighttime values for cSBPMAP/DBPcal were 128, 128, and 125 mm Hg and 115, 117, and 107 mm Hg for cSBPSBP/DBPcal, respectively. We pragmatically propose as upper normal limit for 24-hour cSBPMAP/DBPcal 135 mm Hg and for 24-hour cSBPSBP/DBPcal 120 mm Hg. bSBP dipping (nighttime-daytime/daytime SBP) was -10.6 % in young participants and decreased with increasing age. Central SBPSBP/DBPcal dipping was less pronounced (-8.7% in young participants). In contrast, cSBPMAP/DBPcal dipping was completely absent in the youngest age group and less pronounced in all other participants. These data may serve for comparison in various diseases and have potential implications for refining hypertension diagnosis and management. The different dipping behavior of bSBP versus cSBP requires further investigation.
dc.languageeng
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceessn: 1524-4563
dc.sourcenlmid: 7906255
dc.subjectHypertension
dc.subjectBlood pressure
dc.subjectHeart rate
dc.subjectArterial pressure
dc.titleTwenty-Four-Hour Central (Aortic) Systolic Blood Pressure: Reference Values and Dipping Patterns in Untreated Individuals.
dc.typeArticle
dc.date.updated2022-01-07T16:47:03Z
prism.publicationNameHypertension
dc.identifier.doi10.17863/CAM.79775
rioxxterms.versionofrecord10.1161/HYPERTENSIONAHA.121.17765
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.contributor.orcidWeber, Thomas [0000-0003-0617-0417]
dc.contributor.orcidArgyris, Antonis [0000-0002-8906-6959]
dc.contributor.orcidBanegas, Jose R [0000-0001-6152-9862]
dc.contributor.orcidHametner, Bernhard [0000-0003-2048-1019]
dc.contributor.orcidJankowski, Piotr [0000-0001-6223-8821]
dc.contributor.orcidMaloberti, Alessandro [0000-0002-2612-6264]
dc.contributor.orcidMcDonnell, Barry J [0000-0001-5912-1278]
dc.contributor.orcidAntonio Mota Gomes, Marco [0000-0002-6652-1533]
dc.contributor.orcidMachado Gomes, Annelise [0000-0001-9475-3166]
dc.contributor.orcidLorenza Muiesan, Maria [0000-0002-4007-9441]
dc.contributor.orcidTerentes-Printzios, Dimitrios [0000-0003-4039-8263]
dc.contributor.orcidVlachopoulos, Charalambos [0000-0002-9904-3558]
dc.contributor.orcidWilkinson, Ian [0000-0001-6598-9399]
dc.contributor.orcidSharman, James E [0000-0003-2792-0811]
dc.identifier.eissn1524-4563


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International