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dc.contributor.authorEl-Damanawi, Ragada
dc.contributor.authorLee, Michael
dc.contributor.authorHarris, Tess
dc.contributor.authorCowley, Laura B
dc.contributor.authorScholtes, Ingrid
dc.contributor.authorBond, Simon
dc.contributor.authorSandford, Richard
dc.contributor.authorWilkinson, Ian
dc.contributor.authorCasteleijn, Niek F
dc.contributor.authorHogan, Marie C
dc.contributor.authorKaret Frankl, Fiona E
dc.contributor.authorHiemstra, Thomas F
dc.date.accessioned2022-01-07T16:47:27Z
dc.date.available2022-01-07T16:47:27Z
dc.date.issued2021-11
dc.identifier.issn2048-8505
dc.identifier.otherPMC8573025
dc.identifier.other34754429
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332335
dc.description.abstractBACKGROUND: Pain affects 60% of the autosomal dominant polycystic kidney disease (ADPKD) population. Despite being an early and debilitating symptom, it is poorly characterized and management is suboptimal. This study aimed to develop an ADPKD-specific pain assessment tool (APAT) to facilitate pain research. METHODS: Following a systematic review of PATs used in ADPKD studies and against international recommendations for pain trials, our multi-disciplinary team of clinical experts and patients constructed an ADPKD-pain conceptual framework of key pain evaluation themes. We compiled a new APAT covering domains prioritized within our framework using components of questionnaires validated in other chronic pain disorders. The APAT was administered longitudinally within a randomized high-water intake trial (NCT02933268) to ascertain feasibility and provide pilot data on ADPKD pain. RESULTS: Thirty-nine ADPKD participants with chronic kidney disease Stages 1-4 provided 129 APAT responses. Each participant completed a median of 3 (range 1-10) assessments. Respondents' mean ± standard deviation age was 47 ± 13 years; 59% (23) were female; and 69% (27) had enlarged kidneys with median time from diagnosis 14.2 (interquartile range 7.0-25.9) years. Pain (52%) and associated analgesic use (29%) were common. Pain severity was associated with increasing age [odds ratio (OR) = 1.07, P = 0.009], female gender (OR = 4.34, P = 0.018), estimated glomerular filtration rate <60 mL/min/1.73 m2 (OR = 5.45, P = 0.021) and hypertension (OR = 12.11, P = 0.007), but not with kidney size (P = 0.23). The APAT achieved good internal consistency (Cronbach's alpha coefficient = 0.91) and test-retest reliability (domain intra-class correlation coefficients ranging from 0.62 to 0.90). CONCLUSIONS: The APAT demonstrated good acceptability and reliability, and following further validation in a larger cohort could represent an invaluable tool for future ADPKD pain studies.
dc.description.sponsorshipAddenbrookes Charitable Trust Kidney Care UK British Renal Society Kidney Research UK
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2048-8513
dc.sourcenlmid: 101579321
dc.subjectAnalgesia
dc.subjectPain
dc.subjectChronic pain
dc.subjectPatient-reported Outcomes
dc.subjectAdpkd
dc.titleDeveloping a patient-centred tool for pain measurement and evaluation in autosomal dominant polycystic kidney disease.
dc.typeArticle
dc.date.updated2022-01-07T16:47:27Z
prism.endingPage2348
prism.issueIdentifier11
prism.publicationNameClin Kidney J
prism.startingPage2338
prism.volume14
dc.identifier.doi10.17863/CAM.79781
dcterms.dateAccepted2020-12-02
rioxxterms.versionofrecord10.1093/ckj/sfaa259
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidLee, Michael [0000-0002-5838-2916]
dc.contributor.orcidBond, Simon [0000-0003-2528-1040]
dc.contributor.orcidSandford, Richard [0000-0002-7437-0560]
dc.contributor.orcidWilkinson, Ian [0000-0001-6598-9399]
dc.identifier.eissn2048-8513
pubs.funder-project-idAddenbrooke's Charitable Trust (ACT) (Minute No 24/15A)
pubs.funder-project-idBritish Renal Society (BRS) (unknown)
pubs.funder-project-idKidney Research UK (TF-009-20161125)
cam.issuedOnline2021-02-08


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International