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dc.contributor.authorChen, Lingxiao
dc.contributor.authorFerreira, Manuela L
dc.contributor.authorNassar, Natasha
dc.contributor.authorPreen, David B
dc.contributor.authorHopper, John L
dc.contributor.authorLi, Shuai
dc.contributor.authorBui, Minh
dc.contributor.authorBeckenkamp, Paula R
dc.contributor.authorShi, Baoyi
dc.contributor.authorArden, Nigel K
dc.contributor.authorFerreira, Paulo H
dc.date.accessioned2022-01-07T16:54:02Z
dc.date.available2022-01-07T16:54:02Z
dc.date.issued2021-12
dc.identifier.issn2589-5370
dc.identifier.otherPMC8605211
dc.identifier.other34825152
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332433
dc.description.abstractBACKGROUND: We aimed to quantify the association between chronic musculoskeletal pain and all-cause mortality, and to investigate the extent to which this association is mediated by physical activity, smoking status, alcohol consumption, and opioid use. METHODS: For this population-based cohort study, we used data from UK Biobank, UK between baseline visit (2006-2010) to 18th December 2020. We assessed the associations between chronic musculoskeletal pain and all-cause mortality using a Cox proportional hazards model. We performed causal mediation analyses to examine the proportion of the association between chronic musculoskeletal pain and all-cause mortality. FINDINGS: Of the 384,367 included participants, a total of 187,269 participants reported chronic musculoskeletal pain. Higher number of pain sites was associated with increased risk of all-cause mortality compared to having no pain (e.g., four sites vs no site of pain, Hazard Ratio [HR] 1.46, 95% Confidence Interval [CI] 1.35 to 1.57). The multiple mediator analyses showed that the mediating proportions of all four mediators ranged from 53.4% to 122.6%: among participants with two or more pain sites, the effect estimate reduced substantially, for example, HR reduced from 1.25 (95% CI: 1.21 to 1.30; two pain sites) to 1.07 (95% CI: 1.01 to 1.11; two pain sites). INTERPRETATION: We found that higher number of pain sites was associated with increased risk of all-cause mortality compared to having no pain, and at least half of the association of chronic musculoskeletal pain with increased all-cause mortality may be accounted for by four mediators. FUNDING: Twins Research Australia.
dc.languageeng
dc.publisherElsevier BV
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2589-5370
dc.sourcenlmid: 101733727
dc.titleAssociation of chronic musculoskeletal pain with mortality among UK adults: A population-based cohort study with mediation analysis.
dc.typeArticle
dc.date.updated2022-01-07T16:54:01Z
prism.publicationNameEClinicalMedicine
prism.volume42
dc.identifier.doi10.17863/CAM.79879
dcterms.dateAccepted2021-10-29
rioxxterms.versionofrecord10.1016/j.eclinm.2021.101202
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidChen, Lingxiao [0000-0001-7721-0493]
dc.identifier.eissn2589-5370


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International