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dc.contributor.authorBettgenhaeuser, Jan
dc.contributor.authorHernández-Pinzón, Inmaculada
dc.contributor.authorDawson, Andrew M
dc.contributor.authorGardiner, Matthew
dc.contributor.authorGreen, Phon
dc.contributor.authorTaylor, Jodie
dc.contributor.authorSmoker, Matthew
dc.contributor.authorFerguson, John N
dc.contributor.authorEmmrich, Peter
dc.contributor.authorHubbard, Amelia
dc.contributor.authorBayles, Rosemary
dc.contributor.authorWaugh, Robbie
dc.contributor.authorSteffenson, Brian J
dc.contributor.authorWulff, Brande B H
dc.contributor.authorDreiseitl, Antonín
dc.contributor.authorWard, Eric R
dc.contributor.authorMoscou, Matthew J
dc.date.accessioned2022-01-07T16:54:28Z
dc.date.available2022-01-07T16:54:28Z
dc.date.issued2021-11-25
dc.identifier.issn2041-1723
dc.identifier.otherPMC8617247
dc.identifier.other34824299
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332440
dc.descriptionFunder: Gatsby Charitable Foundation
dc.description.abstractCrop losses caused by plant pathogens are a primary threat to stable food production. Stripe rust (Puccinia striiformis) is a fungal pathogen of cereal crops that causes significant, persistent yield loss. Stripe rust exhibits host species specificity, with lineages that have adapted to infect wheat and barley. While wheat stripe rust and barley stripe rust are commonly restricted to their corresponding hosts, the genes underlying this host specificity remain unknown. Here, we show that three resistance genes, Rps6, Rps7, and Rps8, contribute to immunity in barley to wheat stripe rust. Rps7 cosegregates with barley powdery mildew resistance at the Mla locus. Using transgenic complementation of different Mla alleles, we confirm allele-specific recognition of wheat stripe rust by Mla. Our results show that major resistance genes contribute to the host species specificity of wheat stripe rust on barley and that a shared genetic architecture underlies resistance to the adapted pathogen barley powdery mildew and non-adapted pathogen wheat stripe rust.
dc.languageeng
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2041-1723
dc.sourcenlmid: 101528555
dc.titleThe barley immune receptor Mla recognizes multiple pathogens and contributes to host range dynamics.
dc.typeArticle
dc.date.updated2022-01-07T16:54:26Z
prism.issueIdentifier1
prism.publicationNameNature communications
prism.volume12
dc.identifier.doi10.17863/CAM.79886
rioxxterms.versionofrecord10.1038/s41467-021-27288-3
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidBettgenhaeuser, Jan [0000-0002-6901-1774]
dc.contributor.orcidHernández-Pinzón, Inmaculada [0000-0003-3711-2893]
dc.contributor.orcidGreen, Phon [0000-0002-1968-0574]
dc.contributor.orcidWaugh, Robbie [0000-0003-1045-3065]
dc.contributor.orcidSteffenson, Brian J [0000-0001-7961-5363]
dc.contributor.orcidWulff, Brande B H [0000-0003-4044-4346]
dc.contributor.orcidDreiseitl, Antonín [0000-0002-9137-3210]
dc.contributor.orcidMoscou, Matthew J [0000-0003-2098-6818]
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/P012574/1, BB/J004553/1, BBS/E/J/000PR9795)
pubs.funder-project-idHuman Frontier Science Program (LT000218/2011-L)
pubs.funder-project-idRCUK | Biotechnology and Biological Sciences Research Council (BB/P012574/1, BB/J004553/1, BBS/E/J/000PR9795)
pubs.funder-project-idHuman Frontier Science Program (HFSP) (LT000218/2011-L)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International