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dc.contributor.authorÁlvarez, Eva G
dc.contributor.authorDemeulemeester, Jonas
dc.contributor.authorOtero, Paula
dc.contributor.authorJolly, Clemency
dc.contributor.authorGarcía-Souto, Daniel
dc.contributor.authorPequeño-Valtierra, Ana
dc.contributor.authorZamora, Jorge
dc.contributor.authorTojo, Marta
dc.contributor.authorTemes, Javier
dc.contributor.authorBaez-Ortega, Adrian
dc.contributor.authorRodriguez-Martin, Bernardo
dc.contributor.authorOitaben, Ana
dc.contributor.authorBruzos, Alicia L
dc.contributor.authorMartínez-Fernández, Mónica
dc.contributor.authorHaase, Kerstin
dc.contributor.authorZumalave, Sonia
dc.contributor.authorAbal, Rosanna
dc.contributor.authorRodríguez-Castro, Jorge
dc.contributor.authorRodriguez-Casanova, Aitor
dc.contributor.authorDiaz-Lagares, Angel
dc.contributor.authorLi, Yilong
dc.contributor.authorRaine, Keiran M
dc.contributor.authorButler, Adam P
dc.contributor.authorOtero, Iago
dc.contributor.authorOno, Atsushi
dc.contributor.authorAikata, Hiroshi
dc.contributor.authorChayama, Kazuaki
dc.contributor.authorUeno, Masaki
dc.contributor.authorHayami, Shinya
dc.contributor.authorYamaue, Hiroki
dc.contributor.authorMaejima, Kazuhiro
dc.contributor.authorBlanco, Miguel G
dc.contributor.authorForns, Xavier
dc.contributor.authorRivas, Carmen
dc.contributor.authorRuiz-Bañobre, Juan
dc.contributor.authorPérez-Del-Pulgar, Sofía
dc.contributor.authorTorres-Ruiz, Raúl
dc.contributor.authorRodriguez-Perales, Sandra
dc.contributor.authorGaraigorta, Urtzi
dc.contributor.authorCampbell, Peter J
dc.contributor.authorNakagawa, Hidewaki
dc.contributor.authorVan Loo, Peter
dc.contributor.authorTubio, Jose MC
dc.date.accessioned2022-01-10T11:44:04Z
dc.date.available2022-01-10T11:44:04Z
dc.date.issued2021-11-25
dc.identifier.issn2041-1723
dc.identifier.otherPMC8617174
dc.identifier.other34824211
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332468
dc.description.abstractMost cancers are characterized by the somatic acquisition of genomic rearrangements during tumour evolution that eventually drive the oncogenesis. Here, using multiplatform sequencing technologies, we identify and characterize a remarkable mutational mechanism in human hepatocellular carcinoma caused by Hepatitis B virus, by which DNA molecules from the virus are inserted into the tumour genome causing dramatic changes in its configuration, including non-homologous chromosomal fusions, dicentric chromosomes and megabase-size telomeric deletions. This aberrant mutational mechanism, present in at least 8% of all HCC tumours, can provide the driver rearrangements that a cancer clone requires to survive and grow, including loss of relevant tumour suppressor genes. Most of these events are clonal and occur early during liver cancer evolution. Real-time timing estimation reveals some HBV-mediated rearrangements occur as early as two decades before cancer diagnosis. Overall, these data underscore the importance of characterising liver cancer genomes for patterns of HBV integration.
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2041-1723
dc.sourcenlmid: 101528555
dc.titleAberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture.
dc.typeArticle
dc.date.updated2022-01-10T11:44:04Z
prism.issueIdentifier1
prism.publicationNameNat Commun
prism.volume12
dc.identifier.doi10.17863/CAM.79917
dcterms.dateAccepted2021-10-22
rioxxterms.versionofrecord10.1038/s41467-021-26805-8
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidÁlvarez, Eva G [0000-0002-3522-5088]
dc.contributor.orcidDemeulemeester, Jonas [0000-0002-2660-2478]
dc.contributor.orcidOtero, Paula [0000-0001-5614-1468]
dc.contributor.orcidGarcía-Souto, Daniel [0000-0002-0997-8799]
dc.contributor.orcidTemes, Javier [0000-0003-3370-4728]
dc.contributor.orcidRodriguez-Martin, Bernardo [0000-0003-4693-3140]
dc.contributor.orcidOitaben, Ana [0000-0002-4877-6145]
dc.contributor.orcidBruzos, Alicia L [0000-0003-4362-545X]
dc.contributor.orcidHaase, Kerstin [0000-0002-0944-5618]
dc.contributor.orcidZumalave, Sonia [0000-0002-2108-1861]
dc.contributor.orcidRodríguez-Castro, Jorge [0000-0003-2912-9601]
dc.contributor.orcidRodriguez-Casanova, Aitor [0000-0002-9828-3613]
dc.contributor.orcidRaine, Keiran M [0000-0002-5634-1539]
dc.contributor.orcidOtero, Iago [0000-0002-7924-693X]
dc.contributor.orcidBlanco, Miguel G [0000-0002-2883-7326]
dc.contributor.orcidRuiz-Bañobre, Juan [0000-0003-0755-4295]
dc.contributor.orcidPérez-Del-Pulgar, Sofía [0000-0002-9890-300X]
dc.contributor.orcidTorres-Ruiz, Raúl [0000-0001-9606-0398]
dc.contributor.orcidRodriguez-Perales, Sandra [0000-0001-7221-3636]
dc.contributor.orcidGaraigorta, Urtzi [0000-0002-0683-5725]
dc.contributor.orcidCampbell, Peter J [0000-0002-3921-0510]
dc.contributor.orcidVan Loo, Peter [0000-0003-0292-1949]
dc.contributor.orcidTubio, Jose MC [0000-0003-3540-2459]
dc.identifier.eissn2041-1723
pubs.funder-project-idEuropean Research Council (716290)
cam.issuedOnline2021-11-25


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International