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dc.contributor.authorWinzeler, Bettina
dc.contributor.authorChallis, Benjamin G
dc.contributor.authorCasey, Ruth T
dc.date.accessioned2022-01-10T12:44:26Z
dc.date.available2022-01-10T12:44:26Z
dc.date.issued2021-11-22
dc.identifier.issn2075-4426
dc.identifier.otherPMC8620689
dc.identifier.other34834591
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332469
dc.description.abstractPrecision medicine is a term used to describe medical care, which is specifically tailored to an individual patient or disease with the aim of ensuring the best clinical outcome whilst reducing the risk of adverse effects. Phaeochromocytoma and paraganglioma (PPGL) are rare neuroendocrine tumours with uncertain malignant potential. Over recent years, the molecular profiling of PPGLs has increased our understanding of the mechanisms that drive tumorigenesis. A high proportion of PPGLs are hereditary, with non-hereditary tumours commonly harbouring somatic mutations in known susceptibility genes. Through detailed interrogation of genotype-phenotype, correlations PPGLs can be classified into three different subgroups or clusters. Thus, PPGLs serve as an ideal paradigm for developing, testing and implementing precision medicine concepts in the clinic. In this review, we provide an overview of PPGLs and highlight how detailed molecular characterisation of these tumours provides current and future opportunities for precision oncology.
dc.languageeng
dc.publisherMDPI AG
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2075-4426
dc.sourcenlmid: 101602269
dc.subjectParaganglioma
dc.subjectNeuroendocrine Tumours
dc.subjectPersonalized Medicine
dc.subjectMolecular Clusters
dc.subjectPhaeochromocytoma
dc.titlePrecision Medicine in Phaeochromocytoma and Paraganglioma.
dc.typeArticle
dc.date.updated2022-01-10T12:44:25Z
prism.issueIdentifier11
prism.publicationNameJ Pers Med
prism.volume11
dc.identifier.doi10.17863/CAM.79919
dcterms.dateAccepted2021-11-17
rioxxterms.versionofrecord10.3390/jpm11111239
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidWinzeler, Bettina [0000-0001-8305-2700]
dc.identifier.eissn2075-4426
pubs.funder-project-idGIST SUPPORT UK (n/a)
cam.issuedOnline2021-11-22


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International