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dc.contributor.authorMba, Camille
dc.contributor.authorKoulman, Albert
dc.contributor.authorForouhi, Nita
dc.contributor.authorImamura, F
dc.contributor.authorAssah, F
dc.contributor.authorMbanya, JC
dc.contributor.authorWareham, Nicholas
dc.date.accessioned2022-01-10T12:45:48Z
dc.date.available2022-01-10T12:45:48Z
dc.date.issued2021-12-30
dc.identifier.issn2072-6643
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332489
dc.description.abstractA low intake of fruit and vegetables and a high intake of meat are associated with higher cardiometabolic disease risk; however much prior research has relied on subjective methods for dietary assessment and focused on Western populations. We aimed to investigate the association of blood folate as an objective marker of fruit and vegetable intake and holotranscobalamin (holoTC) as a marker of animal-sourced food intake with cardiometabolic risk factors. We con-ducted a population-based cross-sectional study on 578 adults (mean ± SD age = 38.2 ± 8.6 years; 64% women). The primary outcome was a continuous metabolic syndrome score. The median serum folate was 12.9 (IQR: 8.6–20.5) nmol/L and the mean holoTC was 75 (SD: 34.3) pmol/L. Rural residents demonstrated higher serum folate concentrations (15.9 (9.8–25.9) nmol/L) than urban residents (11.3 (7.9–15.8) nmol/L), but lower holoTC concentrations (rural: 69.8 (32.9) pmol/L; urban: 79.8 (34.9)) pmol/L, p < 0.001 for both comparisons. There was an inverse association between serum folate and metabolic syndrome score by −0.20 in the z-score (95% CI, −0.38 to −0.02) per 10.8 (1 SD) of folate) in a model adjusted for socio-demographic factors, smoking status, alcohol intake, BMI, and physical activity. HoloTC was positively associated with the metabolic syndrome score in unadjusted analysis (0.33 (95% CI, 0.10 to 0.56)) but became non-significant (0.17 (−0.05 to 0.39)) after adjusting for socio-demographic and behavioural characteristics. In conclusion, serum folate and holoTC were associated with the metabolic syndrome score in opposite directions. The positive association between serum holoTC and the metabolic syndrome score was partly dependent on sociodemographic characteristics. These findings suggest that, based on these biomarkers reflecting dietary intakes, public health approaches promoting a higher intake of fruit and vegetables may lower cardiometabolic risk factors in this population.
dc.languageen
dc.publisherMDPI AG
dc.subjectserum folate
dc.subjectholotranscobalamin
dc.subjectcardiometabolic risk factors
dc.titleAssociations of serum folate and holotranscobalamin with cardiometabolic risk factors in rural and urban cameroon
dc.typeArticle
dc.date.updated2022-01-10T12:45:47Z
prism.issueIdentifier1
prism.publicationNameNutrients
prism.volume14
dc.identifier.doi10.17863/CAM.79939
dcterms.dateAccepted2021-12-27
rioxxterms.versionofrecord10.3390/nu14010178
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidKoulman, Albert [0000-0001-9998-051X]
dc.contributor.orcidForouhi, Nita [0000-0002-5041-248X]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.identifier.eissn2072-6643
pubs.funder-project-idMRC (MC_UU_00006/1)
pubs.funder-project-idMRC (MC_UU_00006/3)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NIHR202397)
cam.issuedOnline2021-12-30


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