Show simple item record

dc.contributor.authorde Goffau, Marcus C.
dc.contributor.authorJallow, Amadou T.
dc.contributor.authorSanyang, Chilel
dc.contributor.authorPrentice, Andrew M.
dc.contributor.authorMeagher, Niamh
dc.contributor.authorPrice, David J.
dc.contributor.authorRevill, Peter A.
dc.contributor.authorParkhill, Julian
dc.contributor.authorPereira, Dora I. A.
dc.contributor.authorWagner, Josef
dc.date.accessioned2022-01-10T12:46:32Z
dc.date.available2022-01-10T12:46:32Z
dc.date.issued2021-12-31
dc.date.submitted2021-02-07
dc.identifier.others41564-021-01023-6
dc.identifier.other1023
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332500
dc.descriptionFunder: MRC Unit The Gambia/MRC International Nutrition Group by the UK MRC and the UK Department for the International Development
dc.descriptionFunder: Bill & Melinda Gates Foundation Grand Challenges New Interventions in Global Health award
dc.description.abstractAbstract: Distinct bacterial trophic networks exist in the gut microbiota of individuals in industrialized and non-industrialized countries. In particular, non-industrialized gut microbiomes tend to be enriched with Prevotella species. To study the development of these Prevotella-rich compositions, we investigated the gut microbiota of children aged between 7 and 37 months living in rural Gambia (616 children, 1,389 stool samples, stratified by 3-month age groups). These infants, who typically eat a high-fibre, low-protein diet, were part of a double-blind, randomized iron intervention trial (NCT02941081) and here we report the secondary outcome. We found that child age was the largest discriminating factor between samples and that anthropometric indices (collection time points, season, geographic collection site, and iron supplementation) did not significantly influence the gut microbiome. Prevotella copri, Faecalibacterium prausnitzii and Prevotella stercorea were, on average, the most abundant species in these 1,389 samples (35%, 11% and 7%, respectively). Distinct bacterial trophic network clusters were identified, centred around either P.stercorea or F.prausnitzii and were found to develop steadily with age, whereas P.copri, independently of other species, rapidly became dominant after weaning. This dataset, set within a critical gut microbial developmental time frame, provides insights into the development of Prevotella-rich gut microbiomes, which are typically understudied and are underrepresented in western populations.
dc.languageen
dc.publisherNature Publishing Group UK
dc.subjectArticle
dc.subject/631/326/2565/855
dc.subject/631/326/2565/2134
dc.subject/45/23
dc.subject/45/22
dc.subject/45/77
dc.subjectarticle
dc.titleGut microbiomes from Gambian infants reveal the development of a non-industrialized Prevotella -based trophic network
dc.typeArticle
dc.date.updated2022-01-10T12:46:31Z
prism.endingPage144
prism.issueIdentifier1
prism.publicationNameNature Microbiology
prism.startingPage132
prism.volume7
dc.identifier.doi10.17863/CAM.79950
dcterms.dateAccepted2021-11-11
rioxxterms.versionofrecord10.1038/s41564-021-01023-6
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidPrentice, Andrew M. [0000-0001-5389-451X]
dc.contributor.orcidParkhill, Julian [0000-0002-7069-5958]
dc.contributor.orcidWagner, Josef [0000-0003-1204-7765]
dc.identifier.eissn2058-5276
pubs.funder-project-idBill and Melinda Gates Foundation (Bill & Melinda Gates Foundation) (OPP1140952)


Files in this item

Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record