Tendon healing is adversely affected by low-grade inflammation.
View / Open Files
Publication Date
2021-12-04Journal Title
J Orthop Surg Res
ISSN
1749-799X
Publisher
Springer Science and Business Media LLC
Volume
16
Issue
1
Language
eng
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Chisari, E., Rehak, L., Khan, W. S., & Maffulli, N. (2021). Tendon healing is adversely affected by low-grade inflammation.. J Orthop Surg Res, 16 (1) https://doi.org/10.1186/s13018-021-02811-w
Abstract
BACKGROUND: Tendinopathy is common, presents with pain and activity limitation, and is associated with a high risk of recurrence of the injury. Tendinopathy usually occurs as a results of a disrupted healing response to a primary injury where cellular and molecular pathways lead to low grade chronic inflammation. MAIN FINDINGS: There has been a renewed interest in investigating the role of Inflammation in the pathogenesis of tendinopathy, in particular during the initial phases of the condition where it may not be clinically evident. Understanding the early and late stages of tendon injury pathogenesis would help develop new and effective treatments addressed at targeting the inflammatory pathways. CONCLUSION: This review outlines the role of low-grade Inflammation in the pathogenesis of tendinopathy, stressing the role of proinflammatory cytokines, proteolytic enzymes and growth factors, and explores how Inflammation exerts a negative influence on the process of tendon healing.
Keywords
Healing, Inflammation, Proinflammatory cytokines, Tendinopathy, Humans, Inflammation, Tendinopathy, Tendon Injuries, Tendons, Wound Healing
Identifiers
PMC8642928, 34863223
External DOI: https://doi.org/10.1186/s13018-021-02811-w
This record's URL: https://www.repository.cam.ac.uk/handle/1810/332551
Statistics
Total file downloads (since January 2020). For more information on metrics see the
IRUS guide.
Recommended or similar items
The current recommendation prototype on the Apollo Repository will be turned off on 03 February 2023. Although the pilot has been fruitful for both parties, the service provider IKVA is focusing on horizon scanning products and so the recommender service can no longer be supported. We recognise the importance of recommender services in supporting research discovery and are evaluating offerings from other service providers. If you would like to offer feedback on this decision please contact us on: support@repository.cam.ac.uk