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dc.contributor.authorChisari, Emanuele
dc.contributor.authorRehak, Laura
dc.contributor.authorKhan, Wasim S
dc.contributor.authorMaffulli, Nicola
dc.date.accessioned2022-01-10T12:50:46Z
dc.date.available2022-01-10T12:50:46Z
dc.date.issued2021-12-04
dc.identifier.issn1749-799X
dc.identifier.otherPMC8642928
dc.identifier.other34863223
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332551
dc.description.abstractBACKGROUND: Tendinopathy is common, presents with pain and activity limitation, and is associated with a high risk of recurrence of the injury. Tendinopathy usually occurs as a results of a disrupted healing response to a primary injury where cellular and molecular pathways lead to low grade chronic inflammation. MAIN FINDINGS: There has been a renewed interest in investigating the role of Inflammation in the pathogenesis of tendinopathy, in particular during the initial phases of the condition where it may not be clinically evident. Understanding the early and late stages of tendon injury pathogenesis would help develop new and effective treatments addressed at targeting the inflammatory pathways. CONCLUSION: This review outlines the role of low-grade Inflammation in the pathogenesis of tendinopathy, stressing the role of proinflammatory cytokines, proteolytic enzymes and growth factors, and explores how Inflammation exerts a negative influence on the process of tendon healing.
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 1749-799X
dc.sourcenlmid: 101265112
dc.subjectInflammation
dc.subjectHealing
dc.subjectProinflammatory cytokines
dc.subjectTendinopathy
dc.titleTendon healing is adversely affected by low-grade inflammation.
dc.typeArticle
dc.date.updated2022-01-10T12:50:45Z
prism.issueIdentifier1
prism.publicationNameJ Orthop Surg Res
prism.volume16
dc.identifier.doi10.17863/CAM.80001
dcterms.dateAccepted2020-10-06
rioxxterms.versionofrecord10.1186/s13018-021-02811-w
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidChisari, Emanuele [0000-0003-0933-6806]
dc.identifier.eissn1749-799X
cam.issuedOnline2021-12-04


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International