Show simple item record

dc.contributor.authorMagee, Cormac G
dc.contributor.authorGraham, David
dc.contributor.authorGordon, Charles
dc.contributor.authorDunn, Jason
dc.contributor.authorPenman, Ian
dc.contributor.authorWillert, Robert
dc.contributor.authorSmart, Howard
dc.contributor.authorOrtiz-Fernandez-Sordo, Jacobo
dc.contributor.authorRagunath, Krish
dc.contributor.authorEverson, Martin
dc.contributor.authorAlzoubaidi, Durayd
dc.contributor.authorBanks, Matthew
dc.contributor.authorMorris, Danielle
dc.contributor.authorSami, Sarmed
dc.contributor.authorMorris, Allan J
dc.contributor.authorBhandari, Pradeep
dc.contributor.authorNarayanasamy, Ravi
dc.contributor.authorDi Pietro, Massimiliano
dc.contributor.authorLovat, Laurence B
dc.contributor.authorHaidry, Rehan
dc.date.accessioned2022-01-10T12:51:23Z
dc.date.available2022-01-10T12:51:23Z
dc.date.issued2022-01
dc.date.submitted2020-06-29
dc.identifier.issn0930-2794
dc.identifier.others00464-021-08325-0
dc.identifier.other8325
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332561
dc.description.abstractBACKGROUND: Radio-frequency ablation (RFA) for Barrett's oesophagus (BE)-related neoplasia is currently used after endoscopic resection of visible neoplasia. The HALO 360 balloon has been used to ablate long segment BE. The Barrx™ 360 Express RFA self-sizing catheter ('RFA Express') may potentially allow quicker ablation times and improved treatment outcomes. The aim of this paper is to present real world data on the use of the 360 Express Device. METHODS: Centres in the UK and Ireland submitted cases where the RFA Express was used. The primary outcome was regression of BE at 3 months. Secondary outcomes were the rate of symptomatic stricture formation and resolution of intestinal metaplasia (CR-IM) and dysplasia (CR-D) at End of Treatment (EoT). RESULTS: 11 centres submitted 123 consecutive patients. 112 had a follow up endoscopy. The median age was 67 years (IQR 62-75). 3 dosimetries were used. The mean reduction in Circumferential (C) length was 78% ± 36 and mean reduction in Maximal length (M) was 55% ± 36. 17 patients (15%) developed strictures requiring dilation. There was a higher rate of stricture formation when the 12 J energy was used (p < 0.05). 47 patients had EoT biopsies, 40 (85%) had CR-D and 34(76%) had CR-IM. CONCLUSIONS: The RFA 360 Express catheter shows reduction in length of baseline BE at 3 months after index treatment, and eradication of intestinal metaplasia and dysplasia at 12 months similar to other studies with earlier devices. It appears that the symptomatic stricture rate is slightly higher than previous series with the HALO 360 catheter. This study was performed as part of the HALO registry and has been approved by the Research Ethics Committee - MREC Number 08/H0714/27 Local project reference 08/0104 Project ID 15,033 IRAS Number 54678 EudraCT 2009-015980-1. Registered on ISRCTN as below: ISRCTN93069556. https://doi.org/10.1186/ISRCTN93069556.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectArticle
dc.subjectISRCTN93069556
dc.subjectISRCTN
dc.subjectBarrett’s oesophagus
dc.subjectradio-frequency ablation
dc.subjectStrictures
dc.subjectEarly oesophageal neoplasia
dc.subjectExpress device
dc.titleRadiofrequency ablation for Barrett's oesophagus related neoplasia with the 360 Express catheter: initial experience from the United Kingdom and Ireland-preliminary results.
dc.typeArticle
dc.date.updated2022-01-10T12:51:22Z
prism.endingPage606
prism.issueIdentifier1
prism.publicationNameSurg Endosc
prism.startingPage598
prism.volume36
dc.identifier.doi10.17863/CAM.80011
dcterms.dateAccepted2021-01-13
rioxxterms.versionofrecord10.1007/s00464-021-08325-0
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidDi Pietro, Massimiliano [0000-0003-4866-7026]
dc.contributor.orcidHaidry, Rehan [0000-0003-2063-1857]
dc.identifier.eissn1432-2218
cam.issuedOnline2021-02-05


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record