Aerodynamics and motor control of ultrasonic vocalizations for social communication in mice and rats.
Springer Science and Business Media LLC
MetadataShow full item record
Håkansson, J., Jiang, W., Xue, Q., Zheng, X., Ding, M., Agarwal, A., & Elemans, C. P. (2022). Aerodynamics and motor control of ultrasonic vocalizations for social communication in mice and rats.. BMC Biol, 20 (1) https://doi.org/10.1186/s12915-021-01185-z
BACKGROUND: Rodent ultrasonic vocalizations (USVs) are crucial to their social communication and a widely used translational tool for linking gene mutations to behavior. To maximize the causal interpretation of experimental treatments, we need to understand how neural control affects USV production. However, both the aerodynamics of USV production and its neural control remain poorly understood. RESULTS: Here, we test three intralaryngeal whistle mechanisms-the wall and alar edge impingement, and shallow cavity tone-by combining in vitro larynx physiology and individual-based 3D airway reconstructions with fluid dynamics simulations. Our results show that in the mouse and rat larynx, USVs are produced by a glottal jet impinging on the thyroid inner wall. Furthermore, we implemented an empirically based motor control model that predicts motor gesture trajectories of USV call types. CONCLUSIONS: Our results identify wall impingement as the aerodynamic mechanism of USV production in rats and mice. Furthermore, our empirically based motor control model shows that both neural and anatomical components contribute to USV production, which suggests that changes in strain specific USVs or USV changes in disease models can result from both altered motor programs and laryngeal geometry. Our work provides a quantitative neuromechanical framework to evaluate the contributions of brain and body in shaping USVs and a first step in linking descending motor control to USV production.
Research Article, Bioacoustics, Vocal production, Acoustic communication, Speech, Rodents
Natur og Univers, Det Frie Forskningsråd (7014-00270B)
External DOI: https://doi.org/10.1186/s12915-021-01185-z
This record's URL: https://www.repository.cam.ac.uk/handle/1810/332562
Recommended or similar items
The current recommendation prototype on the Apollo Repository will be turned off on 03 February 2023. Although the pilot has been fruitful for both parties, the service provider IKVA is focusing on horizon scanning products and so the recommender service can no longer be supported. We recognise the importance of recommender services in supporting research discovery and are evaluating offerings from other service providers. If you would like to offer feedback on this decision please contact us on: firstname.lastname@example.org