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dc.contributor.authorDavies, Jack
dc.contributor.authorRonson, Tanya
dc.contributor.authorNitschke, Jonathan
dc.date.accessioned2022-01-11T00:31:04Z
dc.date.available2022-01-11T00:31:04Z
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332590
dc.description.abstractThe vertices of polyhedral protein capsules are spanned by multiple capsule-forming protein subunits, thus enclosing more volume and larger cargoes than if single proteins connect vertices directly. Application of protein cage design principles to synthetic analogues would allow a given ligand to enclose a greater volume. Here we report the self-assembly of a simple tetramine subcomponent into a tetrahedral metal-organic capsule, with each face of the capsule composed of three ligand panels. The edges of the capsule are 31.8 Å in length — double the distance that can be spanned by a single subcomponent. The self-assembly rules followed by this system are programmed into the tetramine — it twists out of planarity in its lowest-energy configuration, thus favouring the large capsule over a simpler cube-like architecture. Unlike other large metal-organic capsules, the cavity of this new capsule is enclosed and the structure was observed to bind large dianionic guests.
dc.description.sponsorshipEuropean Research Council
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleTwisted rectangular subunits self-assemble into a ferritin-like capsule
dc.typeArticle
dc.publisher.departmentDepartment of Chemistry Student
dc.date.updated2022-01-07T15:44:15Z
prism.publicationNameChem
dc.identifier.doi10.17863/CAM.80037
dcterms.dateAccepted2022-01-06
rioxxterms.versionAM
dc.contributor.orcidNitschke, Jonathan [0000-0002-4060-5122]
dc.identifier.eissn2451-9294
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEuropean Research Council (695009)
pubs.funder-project-idEngineering and Physical Sciences Research Council (EP/P027067/1)
pubs.funder-project-idEPSRC (EP/T031603/1)
cam.orpheus.counter6*
cam.depositDate2022-01-07
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2025-01-10


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International