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dc.contributor.authorMba, Camille
dc.contributor.authorKoulman, Albert
dc.contributor.authorForouhi, NG
dc.contributor.authorImamura, F
dc.contributor.authorAssah, F
dc.contributor.authorMbanya, JC
dc.contributor.authorWareham, Nicholas
dc.date.accessioned2022-01-11T00:31:19Z
dc.date.available2022-01-11T00:31:19Z
dc.date.issued2022-01-01
dc.identifier.issn2072-6643
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332593
dc.description.abstractA low intake of fruit and vegetables and a high intake of meat are associated with higher cardiometabolic disease risk; however much prior research has relied on subjective methods for dietary assessment and focused on Western populations. We aimed to investigate the association of blood folate as an objective marker of fruit and vegetable intake and holotranscobalamin (holoTC) as a marker of animal-sourced food intake with cardiometabolic risk factors. We con-ducted a population-based cross-sectional study on 578 adults (mean ± SD age = 38.2 ± 8.6 years; 64% women). The primary outcome was a continuous metabolic syndrome score. The median serum folate was 12.9 (IQR: 8.6–20.5) nmol/L and the mean holoTC was 75 (SD: 34.3) pmol/L. Rural residents demonstrated higher serum folate concentrations (15.9 (9.8–25.9) nmol/L) than urban residents (11.3 (7.9–15.8) nmol/L), but lower holoTC concentrations (rural: 69.8 (32.9) pmol/L; urban: 79.8 (34.9)) pmol/L, p < 0.001 for both comparisons. There was an inverse association between serum folate and metabolic syndrome score by −0.20 in the z-score (95% CI, −0.38 to −0.02) per 10.8 (1 SD) of folate) in a model adjusted for socio-demographic factors, smoking status, alcohol intake, BMI, and physical activity. HoloTC was positively associated with the metabolic syndrome score in unadjusted analysis (0.33 (95% CI, 0.10 to 0.56)) but became non-significant (0.17 (−0.05 to 0.39)) after adjusting for socio-demographic and behavioural characteristics. In conclusion, serum folate and holoTC were associated with the metabolic syndrome score in opposite directions. The positive association between serum holoTC and the metabolic syndrome score was partly dependent on sociodemographic characteristics. These findings suggest that, based on these biomarkers reflecting dietary intakes, public health approaches promoting a higher intake of fruit and vegetables may lower cardiometabolic risk factors in this population.
dc.publisherMDPI AG
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleAssociations of serum folate and holotranscobalamin with cardiometabolic risk factors in rural and urban cameroon
dc.typeArticle
dc.publisher.departmentMrc Epidemiology Unit Student
dc.publisher.departmentDepartment of Clinical Biochemistry
dc.publisher.departmentoffice of The School of Clinical Medicine
dc.date.updated2022-01-07T16:04:40Z
prism.endingPage178
prism.issueIdentifier1
prism.publicationDate2022
prism.publicationNameNutrients
prism.startingPage178
prism.volume14
dc.identifier.doi10.17863/CAM.80040
dcterms.dateAccepted2021-12-27
rioxxterms.versionofrecord10.3390/nu14010178
rioxxterms.versionVoR
dc.contributor.orcidKoulman, Albert [0000-0001-9998-051X]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.identifier.eissn2072-6643
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMRC (MC_UU_00006/1)
pubs.funder-project-idMRC (MC_UU_00006/3)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
cam.issuedOnline2021-12-30
cam.depositDate2022-01-07
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International