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dc.contributor.authorBryce, AN
dc.contributor.authorPhillips, R
dc.contributor.authorSkittrall, Jordan
dc.contributor.authorChakera, AJ
dc.contributor.authorMcLoughlin, JK
dc.contributor.authorSargent, CS
dc.date.accessioned2022-01-13T00:30:43Z
dc.date.available2022-01-13T00:30:43Z
dc.date.issued2020-10
dc.identifier.issn2590-1702
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332664
dc.description.abstractAims: People with type 2 diabetes mellitus are more susceptible to infections. This study aimed to compare the microbiology, incidence and clinical outcome of bloodstream infections (BSIs) in people with type 2 diabetes and matched controls amongst a cohort of hospital inpatients in the United Kingdom. Methods: A retrospective analysis was conducted on all positive blood cultures obtained over a one-year period, identifying inpatients with type 2 diabetes and BSIs (n = 151). Matched controls were collated from the same cohort. Admission data were obtained from clinical coding. Patient outcomes were analysed in terms of 90-day mortality, length of stay (LOS) and admission rate to high or intensive dependency units (HDU/ICU). Microbial culture and clinical source of infection were compared between groups. Results: Patients with type 2 diabetes comprised 10.6% of admissions but 21.1% (n = 151) of analysed BSIs (OR: 2.27, p < .001). Similar 90-day mortality rates were seen between people with type 2 diabetes (D) and controls (C) (D: 23/151, C: 28/151, p = .54). Mean LOS was also similar (D: 19.8 days, C: 21.1 days p = .62). In both groups, Escherichia coli was the most commonly isolated organism (D: 64/173, C: 55/171) and the urinary tract the most common identified primary site of BSI (D: 47/151, C: 45/151). Conclusions: Whilst inpatients with type 2 diabetes have increased odds of experiencing BSIs, our single-centre study suggests a diagnosis of type 2 diabetes does not necessarily confer a worse outcome.
dc.publisherElsevier BV
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleHigher Incidence but Similar Outcomes from Bloodstream Infections in People with Type 2 Diabetes Mellitus: A Retrospective Case-Controlled Analysis
dc.typeArticle
dc.publisher.departmentDepartment of Pathology
dc.date.updated2022-01-01T16:34:21Z
prism.endingPage100030
prism.number100030
prism.publicationDate2020
prism.publicationNameClinical Infection in Practice
prism.startingPage100030
prism.volume7-8
dc.identifier.doi10.17863/CAM.80109
rioxxterms.versionofrecord10.1016/j.clinpr.2020.100030
rioxxterms.versionVoR
dc.contributor.orcidSkittrall, Jordan [0000-0002-8228-3758]
dc.identifier.eissn2590-1702
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMason Medical Research Trust (Unknown)
cam.depositDate2022-01-01
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International