US28: HCMV's Swiss Army Knife.
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Publication Date
2018-08-20Journal Title
Viruses
ISSN
1999-4915
Publisher
MDPI AG
Volume
10
Issue
8
Number
ARTN 445
Pages
445-445
Type
Article
This Version
VoR
Physical Medium
Electronic
Metadata
Show full item recordCitation
Krishna, B. A., Miller, W. E., & O'Connor, C. M. (2018). US28: HCMV's Swiss Army Knife.. Viruses, 10 (8. ARTN 445), 445-445. https://doi.org/10.3390/v10080445
Abstract
US28 is one of four G protein coupled receptors (GPCRs) encoded by human cytomegalovirus (HCMV). The US28 protein (pUS28) is a potent signaling molecule that alters a variety of cellular pathways that ultimately alter the host cell environment. This viral GPCR is expressed not only in the context of lytic replication but also during viral latency, highlighting its multifunctional properties. pUS28 is a functional GPCR, and its manipulation of multiple signaling pathways likely impacts HCMV pathogenesis. Herein, we will discuss the impact of pUS28 on both lytic and latent infection, pUS28-mediated signaling and its downstream consequences, and the influence this viral GPCR may have on disease states, including cardiovascular disease and cancer. We will also discuss the potential for and progress towards exploiting pUS28 as a novel therapeutic to combat HCMV.
Keywords
HCMV, US28, cytomegalovirus, Cardiovascular Diseases, Cytomegalovirus, Cytomegalovirus Infections, Gene Expression Regulation, Viral, Host-Pathogen Interactions, Humans, Models, Molecular, Neoplasms, Protein Structure, Secondary, Receptors, Chemokine, Signal Transduction, Viral Proteins, Virus Latency, Virus Replication
Identifiers
External DOI: https://doi.org/10.3390/v10080445
This record's URL: https://www.repository.cam.ac.uk/handle/1810/332675
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