The Malaysian Acute Vascular Events Risk (MAVERIK) study protocol: studying genetic and other determinants of first-ever myocardial infarction in Malaysia (Preprint)
Authors
Chowdhury, Rajiv
Noh, Mohd Fairulnizal Bin Md
Ismail, Sophia Rasheeqa
van Daalen, Kim Robin
Kamaruddin, Puteri Sofia Nadira Megat
Zulkiply, Siti Hafizah
Azizul, Nur Hayati
Khalid, Norhayati Mustafa
Ali, Azizan
Idris, Izyan Mohd
Mei, Yong Shih
Abdullah, Shazana Rifham
Faridus, Norfashihah
Yusof, Nur Azirah Md
Yusoff, Nur Najwa Farahin M
Jamal, Rahman
Rahim, Aizai Azan Abdul
Radhakrishnan, Ammu Kutty
Ghapar, Abdul Kahar Abdul
Fong, Alan Yean Yip
Ismail, Omar
Krishinan, Saravanan
Yan, Lee Chuey
Bang, Liew Houng
Mageswaren, Eashwary
Mahendran, Kauthaman
Amin, Nor Hanim Mohd
Muthusamy, Gunavathy
Jin, Aaron Ong Hean
Ramli, Ahmad Wazi
Ross, Noel Thomas
Ruhani, Anwar Irawan
Yahya, Mansor
Yusoff, Yusniza
Abidin, Siti Khairani Zainal
Amado, Laryssa
Bolton, Thomas
Weston, Sophie
Crawte, Jason
Ovenden, Niko
Michielsen, Ank
Monower, Md Mostafa
Mahiyuddin, Wan Rozita Wan
Sulaiman, Nur Suffia
Butterworth, Adam S
Journal Title
JMIR Research Protocols
ISSN
1929-0748
Publisher
JMIR Publications Inc.
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Chowdhury, R., Noh, M. F. B. M., Ismail, S. R., van Daalen, K. R., Kamaruddin, P. S. N. M., Zulkiply, S. H., Azizul, N. H., et al. The Malaysian Acute Vascular Events Risk (MAVERIK) study protocol: studying genetic and other determinants of first-ever myocardial infarction in Malaysia (Preprint). JMIR Research Protocols https://doi.org/10.17863/CAM.80250
Abstract
INTRODUCTION: Although the burden of premature myocardial infarction (MI) is high in Malaysia, direct evidence on the determinants of MI in this multi-ethnic population remains sparse. The Malaysian Acute Vascular Events Risk (MAVERIK) study is a retrospective case-control study established to enable investigation of genomic, lipid-related and other determinants of acute MI in Malaysia. To our knowledge, it represents the largest case-control study of MI and related traits in Malaysia. In this paper, we report the study’s design and initial results.
METHODS: By June 2019, MAVERIK had enrolled about 2500 patients with first-ever MI and 2500 controls without cardiovascular disease (CVD), frequency-matched by age, sex and ethnicity, from 17 hospitals in Malaysia. For each participant, serum and whole blood have been collected and stored. Clinical, demographic and behavioural information has been obtained using a 200-item questionnaire.
RESULTS: Tobacco consumption, history of diabetes, hypertension, markers of visceral adiposity, indicators of lower socioeconomic status, and family history of coronary disease were more prevalent in cases than controls. Crude and adjusted (age, sex) logistic regression models for traditional risk factors indicated that current smoking, previous smoking, history of high blood pressure, history of diabetes mellitus, family history of CHD and obesity (BMI>30) were associated with MI in age- and sex-adjusted models.
CONCLUSION: The MAVERIK study can serve as a useful platform to investigate genetic and other risk factors for MI in an under-studied South-East Asian population. It should help to hasten discovery of disease-causing pathways and to inform regionally appropriate strategies that optimise public health action.
Sponsorship
Medical Research Council (MR/P013880/1)
Embargo Lift Date
2025-01-20
Identifiers
This record's DOI: https://doi.org/10.17863/CAM.80250
This record's URL: https://www.repository.cam.ac.uk/handle/1810/332816
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