Machine learning optimized polygenic scores for blood cell traits identify sex-specific trajectories and genetic correlations with disease
View / Open Files
Authors
Xu, Yu
Vuckovic, Dragana
Ritchie, Scott C
Akbari, Parsa
Jiang, Tao
Grealey, Jason
Butterworth, Adam S
Ouwehand, Willem H
Roberts, David J
Soranzo, Nicole
Publication Date
2022-01-12Journal Title
Cell Genomics
ISSN
2666-979X
Publisher
Elsevier BV
Volume
2
Issue
1
Number
100086
Pages
100086-100086
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Xu, Y., Vuckovic, D., Ritchie, S. C., Akbari, P., Jiang, T., Grealey, J., Butterworth, A. S., et al. (2022). Machine learning optimized polygenic scores for blood cell traits identify sex-specific trajectories and genetic correlations with disease. Cell Genomics, 2 (1. 100086), 100086-100086. https://doi.org/10.1016/j.xgen.2021.100086
Abstract
In this issue of Cell Genomics, Xu et al. report a comprehensive analysis of the genetics of 26 blood cell traits, leveraging data from two large biobanks to construct and make available machine-learning optimized polygenic scores (PGSs). In addition to delivering insights into the biology and clinical associations of these traits, the authors evaluate and provide recommendations on methods for PGS construction.
Sponsorship
Medical Research Council (MR/L003120/1)
British Heart Foundation (None)
British Heart Foundation (RG/18/13/33946)
ESRC (ES/T013192/1)
European Commission Horizon 2020 (H2020) Societal Challenges (101016775)
National Institute for Health Research (IS-BRC-1215-20014)
Identifiers
External DOI: https://doi.org/10.1016/j.xgen.2021.100086
This record's URL: https://www.repository.cam.ac.uk/handle/1810/332819
Statistics
Total file downloads (since January 2020). For more information on metrics see the
IRUS guide.
Recommended or similar items
The current recommendation prototype on the Apollo Repository will be turned off on 03 February 2023. Although the pilot has been fruitful for both parties, the service provider IKVA is focusing on horizon scanning products and so the recommender service can no longer be supported. We recognise the importance of recommender services in supporting research discovery and are evaluating offerings from other service providers. If you would like to offer feedback on this decision please contact us on: support@repository.cam.ac.uk