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dc.contributor.authorCodd, V
dc.contributor.authorDenniff, M
dc.contributor.authorSwinfield, C
dc.contributor.authorWarner, SC
dc.contributor.authorPapakonstantinou, M
dc.contributor.authorSheth, S
dc.contributor.authorNanus, DE
dc.contributor.authorBudgeon, CA
dc.contributor.authorMusicha, C
dc.contributor.authorBountziouka, V
dc.contributor.authorWang, Q
dc.contributor.authorBramley, R
dc.contributor.authorAllara, Elias
dc.contributor.authorKaptoge, S
dc.contributor.authorStoma, S
dc.contributor.authorJiang, T
dc.contributor.authorButterworth, Adam
dc.contributor.authorWood, Angela
dc.contributor.authorDi Angelantonio, Emanuele
dc.contributor.authorThompson, JR
dc.contributor.authorDanesh, John
dc.contributor.authorNelson, CP
dc.contributor.authorSamani, NJ
dc.date.accessioned2022-01-21T00:31:01Z
dc.date.available2022-01-21T00:31:01Z
dc.date.issued2022-02
dc.identifier.issn2662-8465
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332822
dc.description.abstractLeukocyte telomere length (LTL) is a proposed marker of biological age. Here we report the measurement and initial characterization of LTL in 474,074 participants in UK Biobank. We confirm that older age and male sex associate with shorter LTL, with women on average ~7 years younger in “biological age” than men. Compared to white Europeans, LTL is markedly longer in African and Chinese ancestries. Older paternal age at birth is associated with longer individual LTL. Higher white cell count is associated with shorter LTL, but proportions of white cell subtypes show weaker associations. Age, ethnicity, sex and white cell count explain ~5.5% of LTL variance. Using paired samples from 1,351 participants taken ~5 years apart, we estimate the within-individual variability in LTL and provide a correction factor for this. This resource provides opportunities to investigate determinants and biomedical consequences of variation in LTL.
dc.publisherSpringer Science and Business Media LLC
dc.rightsAll Rights Reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleMeasurement and initial characterization of leukocyte telomere length in 474,074 participants in UK Biobank
dc.typeArticle
dc.date.updated2022-01-19T15:15:03Z
prism.publicationNameNature Aging
dc.identifier.doi10.17863/CAM.80256
dcterms.dateAccepted2021-12-21
rioxxterms.versionofrecord10.1038/s43587-021-00166-9
rioxxterms.versionAM
dc.contributor.orcidCodd, V [0000-0002-9430-8254]
dc.contributor.orcidPapakonstantinou, M [0000-0003-2664-9046]
dc.contributor.orcidBudgeon, CA [0000-0002-1910-5561]
dc.contributor.orcidAllara, Elias [0000-0002-1634-8330]
dc.contributor.orcidButterworth, Adam [0000-0002-6915-9015]
dc.contributor.orcidWood, Angela [0000-0002-7937-304X]
dc.contributor.orcidDi Angelantonio, Emanuele [0000-0001-8776-6719]
dc.contributor.orcidThompson, JR [0000-0003-4819-1611]
dc.contributor.orcidDanesh, John [0000-0003-1158-6791]
dc.contributor.orcidSamani, NJ [0000-0002-3286-8133]
dc.identifier.eissn2662-8465
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/L003120/1)
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idBritish Heart Foundation (CH/12/2/29428)
pubs.funder-project-idMedical Research Council (MR/M012816/1)
pubs.funder-project-idBritish Heart Foundation (RG/18/13/33946)
pubs.funder-project-idNational Institute for Health Research (NIHRDH-IS-BRC-1215-20014)
cam.issuedOnline2022-02-17
cam.orpheus.successWed Mar 23 10:26:25 GMT 2022 - Embargo updated*
cam.orpheus.counter2
cam.depositDate2022-01-19
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2022-08-17


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