We tested the hypotheses that D2R agonism impairs reversal learning by blocking negative feedback and that antagonism of D1-like receptors (D1R) impairs learning from positive feedback. Male Lister Hooded rats were trained on a novel visual reversal learning task. Performance on “probe trials”, during which the correct or incorrect stimulus was presented with a third, probabilistically rewarded (50% of trials) and therefore intermediate stimulus, revealed individual learning curves for the processes of positive and negative feedback. The effects of D2R and D1R agonists and antagonists were evaluated. A separate cohort was tested on a spatial probabilistic reversal learning (PRL) task after D2R agonism.

There are eight .csv files in this folder, corresponding to the following experiments: (refer to Table 1 in the manuscript) Alsio_2019_quinpirole_PRL.csv -- Cohort VI probabilistic reversal learning Alsio_2019_quinpirole_VPVD_groups.csv -- Cohort II+III quinpirole experiment Alsio_2019_quinpirole_VPVD_trials.csv -- Cohort II+III quinpirole experiment Alsio_2019_Raclo_SCH39166_TSVR_trials.csv -- Cohort IV (TSVR experiment) Alsio_2019_Raclopride_SCH39166_VPVD_groups.csv Cohort IV+V (VPVD experiment) Alsio_2019_raclopride_SCH39166_VPVD_trials.csv Cohort IV+V (VPVD experiment) Alsio_2019_SKF81297_VPVD_groups.csv -- Cohort II+III SKF81297 experiment Alsio_2019_SKF81297_VPVD_trials.csv -- Cohort II+III SKF81297 experiment