Cortical atrophy and amyloid and tau deposition in Down syndrome: A longitudinal study.
Authors
Montal, Victor
Walpert, Madeleine J
Hong, Young T
Fryer, Tim D
Coles, Jonathan P
Aigbirhio, Franklin I
Hartley, Sigan L
Cohen, Ann D
Tudorascu, Dana L
Christian, Bradley T
Handen, Benjamin L
Klunk, William E
Holland, Anthony J
Zaman, Shahid H
Publication Date
2022Journal Title
Alzheimers Dement (Amst)
ISSN
2352-8729
Publisher
Wiley Open Access
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Padilla, C., Montal, V., Walpert, M. J., Hong, Y. T., Fryer, T. D., Coles, J. P., Aigbirhio, F. I., et al. (2022). Cortical atrophy and amyloid and tau deposition in Down syndrome: A longitudinal study.. Alzheimers Dement (Amst) https://doi.org/10.1002/dad2.12288
Abstract
Introduction: The Down syndrome population has a high prevalence for dementia, often showing their first clinical symptoms in their 40s. Methods: In a longitudinal cohort, we investigate whether amyloid deposition at time point 1 (TP1) could predict cortical thickness change at time point 2 (TP2). The association between tau burden and cortical thickness was also examined at time point 3 (TP3). Results: Between TP1 and TP2 there was pronounced cortical thinning in temporo-parietal cortices and cortical thickening in the frontal cortex. Baseline amyloid burden was strongly associated to cortical thinning progression, especially in the temporo-parietal regions. At TP3, tau deposition negatively correlated with cortical atrophy in regions where tau usually accumulates at later Braak stages. Discussion: A higher amount of amyloid accumulation triggers a cascade of changes of disease-causing processes that eventually lead to dementia. As expected, we found that regions where tau usually accumulates were those also displaying high levels of cortical atrophy.
Sponsorship
This research was generously supported by different grants from the Medical Research Council (grant ID number: 98480), the Alzheimer’s Research UK (grant ID number: ARUK-PG2015-23), and the National Institute of Health of the USA (grant ID number: U01AG051406-01 Neurodegeneration in Aging Down Syndrome, NiAD). Additional support came from the NIHR Cambridge Biomedical Research Centre, the NIHR Collaborations in Leadership for Applied Health Research and Care (CLAHRC) for the East of England, the NIHR Cambridge Dementia Biomedical Research Unit, the Down Syndrome Association, and the Health Foundation.
Identifiers
External DOI: https://doi.org/10.1002/dad2.12288
This record's URL: https://www.repository.cam.ac.uk/handle/1810/332969
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